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eIF

eIF Products

All (13)
eIF Inhibitors (13)
New eIF Products

Catalog No.	Product Name	Information	Product Use Citations
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Death Dis, 2024, 15(1):31 Respir Res, 2024, 25(1):201 Cell Genom, 2024, 4(2):100487
S7369	4EGI-1	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.	Nat Commun, 2024, 15(1):4083 Nat Commun, 2024, 15(1):4083 Nucleic Acids Res, 2024, gkae849
S0706	ISRIB	ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation.	Nat Commun, 2024, 15(1):546 Exp Mol Med, 2024, 56(2):408-421. Cell Rep, 2024, 43(7):114487
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	J Clin Invest, 2024, 134(16)e168393 Sci Adv, 2024, 10(37):eadi7673 PLoS Biol, 2023, 21(8):e3002227
S7370	4E1RCat	4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.	Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221 Cell Chem Biol, 2021, S2451-9456(21)00213-0 J Cell Mol Med, 2021, 10.1111/jcmm.16307
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Front Pharmacol, 2023, 14:1095307 bioRxiv, 2023, 2023.05.19.540602 bioRxiv, 2023, 2023.05.19.540602
S7428	Rocaglamide	Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.	Life Sci Alliance, 2024, 7(9)e202302396 Elife, 2023, 12e69521 Blood Adv, 2023, 7(12):2926-2937
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Exp Mol Med, 2024, 56(2):408-421. EMBO J, 2024, 43(5):780-805. Respir Res, 2024, 25(1):201
S8181	SBI-0640756	SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.	Sci Rep, 2021, 11(1):21689
E4888^New	Guanabenz hydrochloride	Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.
S6533	Briciclib	Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S8994^New	Zotatifin	Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Death Dis, 2024, 15(1):31 Respir Res, 2024, 25(1):201 Cell Genom, 2024, 4(2):100487
S7369	4EGI-1	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.	Nat Commun, 2024, 15(1):4083 Nat Commun, 2024, 15(1):4083 Nucleic Acids Res, 2024, gkae849
S0706	ISRIB	ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation.	Nat Commun, 2024, 15(1):546 Exp Mol Med, 2024, 56(2):408-421. Cell Rep, 2024, 43(7):114487
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	J Clin Invest, 2024, 134(16)e168393 Sci Adv, 2024, 10(37):eadi7673 PLoS Biol, 2023, 21(8):e3002227
S7370	4E1RCat	4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.	Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221 Cell Chem Biol, 2021, S2451-9456(21)00213-0 J Cell Mol Med, 2021, 10.1111/jcmm.16307
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Front Pharmacol, 2023, 14:1095307 bioRxiv, 2023, 2023.05.19.540602 bioRxiv, 2023, 2023.05.19.540602
S7428	Rocaglamide	Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.	Life Sci Alliance, 2024, 7(9)e202302396 Elife, 2023, 12e69521 Blood Adv, 2023, 7(12):2926-2937
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Exp Mol Med, 2024, 56(2):408-421. EMBO J, 2024, 43(5):780-805. Respir Res, 2024, 25(1):201
S8181	SBI-0640756	SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.	Sci Rep, 2021, 11(1):21689
E4888^New	Guanabenz hydrochloride	Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.
S6533	Briciclib	Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S8994^New	Zotatifin	Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
E4888^New	Guanabenz hydrochloride	Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.
S8994^New	Zotatifin	Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.

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