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eIF

eIF Products

All (11)
eIF Inhibitors (11)
New eIF Products

Catalog No.	Product Name	Information	Product Use Citations
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Death Dis, 2024, 15(1):31 Respir Res, 2024, 25(1):201 Cell Rep, 2023, 42(2):112042
S7369	4EGI-1	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.	Nat Commun, 2024, 15(1):4083 Nat Commun, 2024, 15(1):4083 Brain Sci, 2023, 13(5)745
S0706	ISRIB	ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation.	Nat Commun, 2024, 15(1):546 Exp Mol Med, 2024, 56(2):408-421. Respir Res, 2024, 25(1):201
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	PLoS Biol, 2023, 21(8):e3002227 Hum Exp Toxicol, 2023, 42:9603271231158047 JCI Insight, 2022, 7(22e158060)
S7370	4E1RCat	4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.	Cell Chem Biol, 2021, S2451-9456(21)00213-0 J Cell Mol Med, 2021, 10.1111/jcmm.16307 Int J Ophthalmol, 2020, 13(1):7-10
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Front Pharmacol, 2023, 14:1095307 bioRxiv, 2023, 2023.05.19.540602 bioRxiv, 2023, 2023.05.19.540602
S7428	Rocaglamide	Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.	Elife, 2023, 12e69521 Blood Adv, 2023, 7(12):2926-2937
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Exp Mol Med, 2024, 56(2):408-421. EMBO J, 2024, 43(5):780-805. Respir Res, 2024, 25(1):201
S8181	SBI-0640756	SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.	Sci Rep, 2021, 11(1):21689
S6533	Briciclib	Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Death Dis, 2024, 15(1):31 Respir Res, 2024, 25(1):201 Cell Rep, 2023, 42(2):112042
S7369	4EGI-1	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with K_D of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.	Nat Commun, 2024, 15(1):4083 Nat Commun, 2024, 15(1):4083 Brain Sci, 2023, 13(5)745
S0706	ISRIB	ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation.	Nat Commun, 2024, 15(1):546 Exp Mol Med, 2024, 56(2):408-421. Respir Res, 2024, 25(1):201
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	PLoS Biol, 2023, 21(8):e3002227 Hum Exp Toxicol, 2023, 42:9603271231158047 JCI Insight, 2022, 7(22e158060)
S7370	4E1RCat	4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.	Cell Chem Biol, 2021, S2451-9456(21)00213-0 J Cell Mol Med, 2021, 10.1111/jcmm.16307 Int J Ophthalmol, 2020, 13(1):7-10
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.	Front Pharmacol, 2023, 14:1095307 bioRxiv, 2023, 2023.05.19.540602 bioRxiv, 2023, 2023.05.19.540602
S7428	Rocaglamide	Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.	Elife, 2023, 12e69521 Blood Adv, 2023, 7(12):2926-2937
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Exp Mol Med, 2024, 56(2):408-421. EMBO J, 2024, 43(5):780-805. Respir Res, 2024, 25(1):201
S8181	SBI-0640756	SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.	Sci Rep, 2021, 11(1):21689
S6533	Briciclib	Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1

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