Home Cell Cycle eIF inhibitor SBI-0640756 For research use only.

SBI-0640756

Synonyms: SBI-756

SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.

SBI-0640756 Chemical Structure

SBI-0640756 Chemical Structure

CAS No. 1821280-29-8

Purity & Quality Control

Batch: S818101 DMSO]80 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.89%
99.89

SBI-0640756 Related Products

Biological Activity

Description SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.
Targets
eIF4G1 [1]
In vitro
In vitro

SBI-756 impaired the eIF4F complex assembly independently of mTOR and attenuated growth of BRAF-resistant and BRAF-independent melanomas.It also supresses AKT and NF-kB signaling. SBI-756 inhibits the growth of NRAS, BRAF, and NF1-mutant melanomas in vitro[1].
Cell Research Cell lines Melanoma lines
Concentrations 1, 2, 5 μmol/L
Incubation Time 48 h
Method

Melanoma lines are plated (triplicates 384-well plates; 1,500 cells per well) and cell viability is assessed 48 hours after treatment with indicated compounds. Growth inhibition is calculated as percentage of DMSO-treated controls and is plotted against the log drug concentration.
In Vivo
In vivo

SBI-756 delays the onset and reduces the incidence of Nras/Ink4a melanomas in vivo[1].

Chemical Information & Solubility

Molecular Weight 404.82 Formula

C23H14ClFN2O2
CAS No. 1821280-29-8 SDF Download SBI-0640756 SDF
Smiles C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)C=CC4=CC(=CN=C4)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 80 mg/mL ( (197.61 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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