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DNA alkylator

Isoform-selective Products

AGT

DNA alkylator Products

All (18)
DNA alkylator Inhibitors (3)
DNA alkylator Activator (1)
DNA alkylator Modulators (2)
New DNA alkylator Products

Catalog No.	Product Name	Information	Product Use Citations
S1224	Oxaliplatin	Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Mol Cancer, 2024, 23(1):186 Mol Cancer, 2024, 23(1):23 Gastroenterology, 2024, S0016-5085(24)00062-3
S1215	Carboplatin	Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S2057	Cyclophosphamide Monohydrate	Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.	BMC Cancer, 2024, 24(1):185 Nat Commun, 2023, 14(1):7576 EMBO Mol Med, 2023, 15(12):e18199
S1312	STZ (Streptozotocin)	STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Streptozotocin (STZ) can be used to induce animal models of diabetes. Solutions are unstable and should be fresh-prepared.	Cell Commun Signal, 2024, 22(1):368 Fluids Barriers CNS, 2024, 21(1):26 CNS Neurosci Ther, 2024, 30(8):e14913
S1692	Busulfan	Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.	J Immunother Cancer, 2024, 12(11)e009805 Nat Commun, 2022, 13(1):6110 Blood Cancer Discov, 2022, 3(2):154-169
S8266	Melphalan	Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Cell Death Dis, 2024, 15(8):588 Front Immunol, 2024, 15:1470328 Heliyon, 2024, 10(1):e23165
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S1278	Altretamine	Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S8056	Lomeguatrib	Lomeguatrib (PaTrin-2) is a potent inhibitor of O⁶-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.	Sci Rep, 2024, 14(1):12363 Neurooncol Adv, 2024, 6(1):vdad165 Int J Mol Sci, 2023, 24(20)15179
S3658	O6-Benzylguanine	O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 Neuro Oncol, 2021, 23(6):920-931
E0609	Methyl methanesulfonate	Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.	Int J Biol Sci, 2024, 20(11):4513-4531 Cell Rep, 2024, 43(2):113779 J Transl Med, 2023, 21(1):183
S8880	Lobaplatin (D-19466)	Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Int J Nanomedicine, 2024, 19:9503-9547 Biochem Pharmacol, 2020, 12:114023
S6984	Dianhydrogalactitol (VAL-083)	Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
E4754^New	Semustine	Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
S7829	Tretazicar (CB1954)	Tretazicar (CB1954) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.	Biochem J, 2024, 481(6):405-422
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S1215	Carboplatin	Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S8056	Lomeguatrib	Lomeguatrib (PaTrin-2) is a potent inhibitor of O⁶-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.	Sci Rep, 2024, 14(1):12363 Neurooncol Adv, 2024, 6(1):vdad165 Int J Mol Sci, 2023, 24(20)15179
S3658	O6-Benzylguanine	O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 Neuro Oncol, 2021, 23(6):920-931
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S4447	Pipobroman	Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958	Treosulfan	Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
E4754^New	Semustine	Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.

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