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O6-Benzylguanine
Synonyms: O6-BG
O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
O6-Benzylguanine Chemical Structure
CAS No. 19916-73-5
Purity & Quality Control
Batch:
S365801
DMSO]48 mg/mL]false]Ethanol]12 mg/mL]false]Water]Insoluble]false
Purity:
99.91%
99.91
O6-Benzylguanine Related Products
| Related Targets | AGT | Click to Expand |
|---|---|---|
| Related Products | Lomeguatrib Methyl methanesulfonate Lobaplatin (D-19466) | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Apoptosis Compound Library DNA Damage/DNA Repair compound Library Cell Cycle compound library | Click to Expand |
Biological Activity
| Description | O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. | |
|---|---|---|
| Targets |
|
| In vitro | ||||
| In vitro | Pirenzepine is a antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions[1]. | |||
|---|---|---|---|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00275002 | Completed | Brain and Central Nervous System Tumors |
National Cancer Institute (NCI) |
February 2006 | Phase 2 |
| NCT00086970 | Terminated | Unspecified Adult Solid Tumor Protocol Specific |
National Cancer Institute (NCI) |
June 2004 | Phase 1 |
| NCT00613093 | Completed | Glioblastoma Multiforme|Anaplastic Glioma |
Duke University|Keryx / AOI Pharmaceuticals Inc.|National Institutes of Health (NIH) |
October 2002 | Phase 2 |
| NCT00005981 | Completed | Colorectal Cancer |
Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
June 2000 | Phase 2 |
| NCT00004072 | Completed | Multiple Myeloma and Plasma Cell Neoplasm |
Case Comprehensive Cancer Center|National Cancer Institute (NCI) |
September 1999 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 241.25 | Formula | C12H11N5O |
| CAS No. | 19916-73-5 | SDF | Download O6-Benzylguanine SDF |
| Smiles | C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N | ||
| Storage (From the date of receipt) | |||
|
In vitro |
DMSO : 48 mg/mL ( (198.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 12 mg/mL Water : Insoluble |
Molecular Weight Calculator |
|
In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Preparing Stock Solutions
Molarity Calculator
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
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%
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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