Home DNA Damage/DNA Repair DNA alkylator modulator Treosulfan For research use only.

Treosulfan

Synonyms: NSC 39069, Treosulphan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

Treosulfan Chemical Structure

Treosulfan Chemical Structure

CAS No. 299-75-2

Purity & Quality Control

Batch: S695801 DMSO]56 mg/mL]false]Water]56 mg/mL]false]Ethanol]Insoluble]false Purity: 98.97%
98.97

Treosulfan Related Products

Biological Activity

Description

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05534620 Recruiting
Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS)|Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
medac GmbH|Synteract Inc.
 February 1 2024 Phase 1
NCT05636787 Recruiting
Multiple Myeloma
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 June 6 2023 Phase 2
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Acute Lymphoblastic Leukaemias (ALL)|Acute Myeloid Leukaemias (AML)|Myelodysplastic Syndromes (MDS)|Juvenile Myelomonocytic Leukaemias (JMML)
medac GmbH|Celerion|Syneos Health
 November 21 2014 Phase 2
NCT02048800 Completed
Allogeneic Haematopoietic Stem Cell Transplantation
Great Ormond Street Hospital for Children NHS Foundation Trust|Newcastle-upon-Tyne Hospitals NHS Trust
 March 2014 --
NCT01772953 Completed
Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Center for International Blood and Marrow Transplant Research|National Marrow Donor Program|Resource for Clinical Investigation in Blood and Marrow Transplantation (RCI BMT)|Pediatric Blood and Marrow Transplant Consortium|St. Baldrick''s Foundation|medac GmbH
 September 2013 Phase 2
NCT01063647 Completed
Hematological Malignancies
medac GmbH
 November 2001 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 278.30 Formula

C6H14O8S2
CAS No. 299-75-2 SDF --
Smiles C[S](=O)(=O)OCC(O)C(O)CO[S](C)(=O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 56 mg/mL ( (201.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 56 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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