SGLT2 Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
s5566	Dapagliflozin propanediol monohydrate	Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.	Selective
S4431	Ertugliflozin L-pyroglutamic acid	Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.	Selective	h-SGLT2, IC50: 0.877 nM
S5413	Ertugliflozin	Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.	Selective	hSGLT2, IC50: 0.877 nM
S1548	Dapagliflozin	Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.	Selective	hSGLT2, EC50: 1.1 nM
S8103	Sotagliflozin	Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.	Selective	SGLT2, IC50: 1.8 nM
S5901	Canagliflozin hemihydrate	Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Selective	mSGLT2, IC50: 2 nM; hSGLT2, IC50: 4.4 nM
S2760	Canagliflozin (JNJ 28431754)	Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.	Selective	hSGLT2, IC50: 4.4 nM; rSGLT2, IC50: 3.7 nM; mSGLT2, IC50: 2 nM
S8558	Tofogliflozin(CSG 452)	Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.	Selective	hSGLT2, IC50: 2.9 nM
S8022	Empagliflozin	Empagliflozin is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.	Selective	SGLT2, IC50: 3.1 nM
S8637	Ipragliflozin (ASP1941)	Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.	Selective	hSGLT2, IC50: 7.4 nM; rat SGLT2, IC50: 6.73 nM; mouse SGLT2, IC50: 5.64 nM
S0994	Ipragliflozin L-Proline	Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.	Selective	human SGLT2, IC50: 7.38 nM; rat SGLT2, IC50: 6.73 nM; mouse SGLT2, IC50: 5.64 nM
S2343	Phlorizin	Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.	Pan	hSGLT2, Ki: 39 nM
S2342	Phloretin (RJC 02792)	Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.	Pan