Home GPCR & G Protein SGLT inhibitor Ipragliflozin L-Proline For research use only.

Ipragliflozin L-Proline

Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.

Ipragliflozin L-Proline Chemical Structure

Ipragliflozin L-Proline Chemical Structure

CAS No. 951382-34-6

Purity & Quality Control

Batch: S099401 DMSO]35 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.37%
99.37

Ipragliflozin L-Proline Related Products

Signaling Pathway

SGLT Signaling Pathways

SGLT Signaling Pathway

Biological Activity

Description Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.
Targets
mouse SGLT2 [1]
(Cell-free assay)		 rat SGLT2 [1]
(Cell-free assay)		 human SGLT2 [1]
(Cell-free assay)
5.64 nM 6.73 nM 7.38 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02794792 Completed
Type 2 Diabetes Mellitus
Astellas Pharma Europe B.V.|Astellas Pharma Inc
 May 11 2016 Phase 3
NCT01611363 Completed
Type 2 Diabetes Mellitus
Astellas Pharma Europe B.V.|Astellas Pharma Inc
 October 27 2011 Phase 1
NCT01611415 Completed
Healthy Subjects|Pharmacokinetics of Ipragliflozin
Astellas Pharma Europe B.V.|Astellas Pharma Inc
 July 2011 Phase 1
NCT01611428 Completed
Bioavailability of Ipragliflozin|Healthy Subjects
Astellas Pharma Europe B.V.|Astellas Pharma Inc
 June 2011 Phase 1

Chemical Information & Solubility

Molecular Weight 519.58 Formula

C26H30FNO7S
CAS No. 951382-34-6 SDF --
Smiles C1CC(NC1)C(=O)O.C1=CC=C2C(=C1)C=C(S2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 35 mg/mL ( (67.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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