Home GPCR & G Protein SGLT inhibitor Phloretin (RJC 02792) For research use only.

Phloretin (RJC 02792)

Synonyms: NSC 407292, Dihydronaringenin

Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

Phloretin (RJC 02792) Chemical Structure

Phloretin (RJC 02792) Chemical Structure

CAS No. 60-82-2

Purity & Quality Control

Phloretin (RJC 02792) Related Products

Signaling Pathway

SGLT Signaling Pathways

SGLT Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H1299 cells Function assay 30 mins Inhibition of GLUT1 in human H1299 cells assessed as inhibition of 2-deoxy-D-[3H]-glucose uptake incubated for 15 mins prior to 2-deoxy-D-[3H]-glucose addition measured after 30 mins by liquid scintillation counting analysis, IC50=21.4 Μm 24200808
PK15NTD cells Function assay Binding affinity to human recombinant CNT3 expressed in pig PK15NTD cells assessed as [3H]uridine uptake by beta-scintillation, Ki=32.28 μM 19097778
Click to View More Cell Line Experimental Data

Biological Activity

Description Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
Targets
SGLT1 [1] SGLT2 [1]
In vitro
In vitro Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05073523 Completed
Healthy
Chalmers University of Technology
 September 27 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 274.27 Formula

C15H14O5
CAS No. 60-82-2 SDF Download Phloretin (RJC 02792) SDF
Smiles C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 55 mg/mL ( (200.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 55 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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