Home JAK/STAT JAK inhibitor Zasocitinib For research use only.

Zasocitinib

Synonyms: NDI-034858; TAK-279

Zasocitinib( NDI-034858, TAK-279) is a TYK2 inhibitor, which is currently being investigated in a phase IIb trial for moderate-to-severe plaque psoriasis.

Zasocitinib Chemical Structure

Zasocitinib Chemical Structure

CAS No. 2272904-53-5

Purity & Quality Control

Batch: E152601 DMSO]31 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.91%
99.91

Zasocitinib Related Products

Signaling Pathway

JAK Signaling Pathways

JAK Signaling Pathway

Biological Activity

Description Zasocitinib( NDI-034858, TAK-279) is a TYK2 inhibitor, which is currently being investigated in a phase IIb trial for moderate-to-severe plaque psoriasis.
Targets
TYK2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06111547 Not yet recruiting
Healthy Volunteers
Takeda
 May 30 2024 Phase 1
NCT06290050 Recruiting
Healthy Volunteers
Takeda
 March 29 2024 Phase 1
NCT06108544 Recruiting
Plaque Psoriasis
Takeda
 November 6 2023 Phase 3
NCT06088043 Recruiting
Plaque Psoriasis
Takeda
 November 6 2023 Phase 3
NCT05992155 Recruiting
Renal Impairment|Healthy Volunteers
Takeda
 September 27 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 460.49 Formula

C23H24N8O3
CAS No. 2272904-53-5 SDF Download Zasocitinib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 31 mg/mL ( (67.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Zasocitinib | Zasocitinib supplier | purchase Zasocitinib | Zasocitinib cost | Zasocitinib manufacturer | order Zasocitinib | Zasocitinib distributor