Home Transmembrane Transporters Potassium Channel inhibitor XE991 dihydrochloride For research use only.

XE991 dihydrochloride

Synonyms: LS190926 dihydrochloride

XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.

XE991 dihydrochloride Chemical Structure

XE991 dihydrochloride Chemical Structure

CAS No. 122955-13-9

Purity & Quality Control

Batch: S296701 Water]90 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.24%
99.24

XE991 dihydrochloride Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.
Targets
KCNQ2 + KCNQ3 channel [1]
(Cell-free assay)		 KCNQ2 [1]
(Cell-free assay)		 KCNQ1 [1]
(Cell-free assay)		 M-current [1]
(Cell-free assay)
0.6 μM 0.71 μM 0.75 μM 0.98 μM

Chemical Information & Solubility

Molecular Weight 449.37 Formula

C26H22Cl2N2O
CAS No. 122955-13-9 SDF --
Smiles Cl.Cl.O=C1C2=CC=CC=C2C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 90 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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