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Xanthoxyline

Synonyms: Brevifolin

Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin.

Xanthoxyline Chemical Structure

Xanthoxyline Chemical Structure

CAS No. 90-24-4

Purity & Quality Control

Batch: S478101 DMSO]39 mg/mL]false]]]false]]]false Purity: 99.93%
99.93

Xanthoxyline Related Products

Biological Activity

Description Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin.
In vitro
In vitro Xanthoxylin (RCX) exhibits potent cytotoxicity in a panel of different cancer cells. It presents IC50 values of 1.6 and 26.0 μM for the HCT116 and ACP-03 cancer cell lines, respectively. Xanthoxylin causes apoptosis in a time- and concentration-dependent manner and induces mitochondrial depolarization in HepG2 cells. It induces DNA intercalation, inhibited DNA synthesis and triggered the caspase-mediated apoptosis pathway in HepG2 cells, as observed by cell shrinkage, internucleosomal DNA fragmentation, externalization of phosphatidylserine, loss of mitochondrial transmembrane potential and activation of caspase-3, -8 and -9[1]. Xanthoxylin increases melanin production, number of dendrites, tyrosinase, and microphthalmia-associated transcription factor (MITF) expression in cultured B16F10 cells[2].
Cell Research Cell lines HepG2 cells
Concentrations 12 and 24 μM
Incubation Time 12, 24, 48 or 72 h
Method The cell viability of HepG2 cells is determined by the trypan blue staining after 12, 24, 48 and 72 h of incubation.
In Vivo
In vivo Xanthoxylin presents a potent in vivo antitumor effect in C.B-17 SCID mice engrafted with HepG2 cells[1].
Animal Research Animal Models C.B-17 severe combined immunodeficient (SCID) mice engrafted with HepG2 cells
Dosages 2.5 and 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 196.20 Formula

C10H12O4
CAS No. 90-24-4 SDF Download Xanthoxyline SDF
Smiles CC(=O)C1=C(C=C(C=C1OC)OC)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (198.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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