S7418 |
Cycloheximide
|
Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
-
Signal Transduct Target Ther, 2024, 9(1):65
-
Mol Cancer, 2024, 23(1):143
-
Cell Metab, 2024, 36(7):1598-1618.e11
|
|
S2476 |
Itraconazole
|
Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy. |
-
Front Cell Infect Microbiol, 2023, 13:1128000
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Front Cell Infect Microbiol, 2022, 12:864912
|
|
S1442 |
Voriconazole
|
Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. |
-
Pharmaceutics, 2024, 16(7)897
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Front Cell Infect Microbiol, 2022, 12:864912
|
|
S1331 |
Fluconazole
|
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
-
Front Cell Infect Microbiol, 2024, 14:1296151
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Nat Commun, 2022, 13(1):1658
|
|
S1353 |
Ketoconazole
|
Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor. |
-
J Med Virol, 2023, 95(6):e28856
-
J Med Virol, 2023, 95(6):e28856
-
Cell Death Dis, 2023, 14(1):64
|
|
S3073 |
Caspofungin (MK-0991) Acetate
|
Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor. |
-
PLoS Pathog, 2024, 20(9):e1012521
-
Viruses, 2023, 15(2)452
-
BMC Med, 2022, 20(1):359
|
|
S1934 |
Nystatin
|
Nystatin(Fungicidin), which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis. |
-
Microbiol Spectr, 2023, 10.1128/spectrum.02553-23
-
Nature, 2022, 603(7899):159-165
-
Nat Metab, 2022, 4-10:1369-1401
|
|
S4286 |
Anidulafungin
|
Anidulafungin, an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
|
-
Viruses, 2023, 15(2)452
-
BMC Med, 2022, 20(1):359
-
Antiviral Res, 2021, S0166-3542(21)00178-9
|
|
S4287 |
Micafungin Sodium
|
Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
|
-
Microbiol Spectr, 2024, e0352623.
-
BMC Med, 2022, 20(1):359
-
Antiviral Res, 2021, S0166-3542(21)00178-9
|
|
S3019 |
Ciclopirox ethanolamine
|
Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator. |
-
Commun Biol, 2023, 6(1):402
-
Commun Biol, 2023, 6(1):402
-
J Clin Invest, 2022, 132(9)e152345
|
|
S2058 |
Tolnaftate
|
Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent. |
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S2321 |
Magnolol
|
Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation. |
-
Mol Oncol, 2022, 16(15):2823-2842
-
Int Immunopharmacol, 2022, 112:109242
-
Reprod Biol, 2021, 21(4):100567
|
|
S1725 |
Terbinafine
|
Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth. |
-
Front Oncol, 2023, 13:1111570
-
Neurooncol Adv, 2022, 4(1):vdac018
-
J Cell Mol Med, 2020, 25
|
|
S1956 |
Miconazole Nitrate
|
Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections. |
-
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
-
Chem Biol Interact, 2021, 343:109498
-
Biomol Ther (Seoul), 2020, 25
|
|
S2528 |
Ciclopirox
|
Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator. |
-
Cell Death Dis, 2021, 12(12):1141
-
J Transl Med, 2021, 19(1):347
-
Int J Mol Sci, 2021, 22(15)8299
|
|
S3079 |
Atovaquone
|
Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. |
-
Cells, 2024, 13(12)1025
-
iScience, 2024, 27(3):109172
-
J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S1606 |
Clotrimazole
|
Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections. |
-
iScience, 2022, 25(11):105342
-
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
-
J Cell Physiol, 2020, 10.1002
|
|
S2557 |
Terbinafine HCl
|
Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug. |
-
Cell Rep Med, 2023, S2666-3791(22)00494-3
-
Oncogene, 2021, 10.1038/s41388-021-01934-y
-
J Cell Mol Med, 2020, 25
|
|
S2536 |
Miconazole
|
Miconazole (Monistat,R18134) is an imidazole antifungal agent. |
-
Nat Commun, 2024, 15(1):3068
-
Int J Mol Sci, 2022, 23(22)13809
-
Chem Biol Interact, 2021, 343:109498
|
|
S1676 |
Amorolfine HCl
|
Amorolfine HCl(Ro 14-4767 HCl) is an antifungal reagent. |
-
Nat Commun, 2021, 12(1):652
-
Cell Chem Biol, 2019, 26(4):593-599
-
Nature, 2018, 560(7718):372-376
|
|
S4075 |
Zinc Pyrithione
|
Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. |
-
Cell Chem Biol, 2021, S2451-9456(21)00213-0
-
Biol Reprod, 2019, 100(2):468-478
-
Cell Syst, 2017, 4(6-:600-610
|
|
S5080 |
Neticonazole
|
Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity. |
-
Nat Commun, 2023, 14(1):6692
-
Nat Commun, 2023, 14(1):6692
-
Clin Transl Med, 2022, 12(9):e1037
|
|
S1517 |
Natamycin
|
Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference |
-
Expert Opin Drug Deliv, 2020, 17(3):407-421
-
BMC Microbiol, 2020, 20(1):275
|
|
S2535 |
Econazole nitrate
|
Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. |
-
Nat Commun, 2024, 15(1):8708
-
Cell Rep Med, 2023, 4(12):101309
-
Int J Mol Sci, 2022, 23(22)13809
|
|
S1910 |
Tioconazole
|
Tioconazole (UK-20349) is an antifungal medication with an average IC50 of 1.7 μM. |
-
J Mol Cell Biol, 2021, mjab059
-
Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
|
|
S4120 |
Sulconazole Nitrate
|
Sulconazole Nitrate(Exelderm,RS 44872) is an imidazole derivative with broad-spectrum antifungal activity. |
-
Int J Mol Sci, 2022, 23(22)13809
-
Sci Adv, 2021, 7(36):eabf6033
|
|
S4601 |
Clioquinol
|
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. |
-
Cancer Lett, 2024, 588:216797
-
Mol Oncol, 2021, 10.1002/1878-0261.13079
-
FASEB J, 2019, 10.1096/fj.201802603RR
|
|
S5373 |
Pseudolaric Acid B
|
Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties. |
-
Toxicology, 2023, 493:153556
-
Eur J Pharmacol, 2020, 876:173064
|
|
S1666 |
Flucytosine (5-Fluorocytosine)
|
Flucytosine (5-Fluorocytosine) is an antifungal drug with IC50 of 0.93 μM in C. albicans. |
-
Sci Adv, 2021, 7(27)eabh3032
|
|
S1854 |
Bifonazole
|
Bifonazole (Bay h 4502,(±)-bifonazole) is a substituted imidazole antifungal agent. |
-
Nature, 2018, 560(7718):372-376
|
|
S3161 |
Sertaconazole nitrate
|
Sertaconazole nitrate (FI-7045,FI7056) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections. |
-
Int J Mol Sci, 2022, 23(22)13809
|
|
S5359 |
Butoconazole
|
Butoconazole is an imidazole antifungal used in gynecology. |
-
Arch Biochem Biophys, 2024, 754:109958
-
Nature, 2018, 560(7718):372-376
|
|
S8095 |
Tubercidin
|
Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. |
-
Mol Cell, 2020, 80(6):1104-1122.e9
|
|
S4584 |
Butylparaben
|
Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products. |
-
Environ Toxicol, 2018, 33(4):436-445
|
|
S4178 |
Climbazole
|
Climbazole(BAY-e 6975) is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits. |
-
Sci Adv, 2022, 8(49):eadd2191
|
|
S3646 |
Thimerosal
|
Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
-
EMBO J, 2024, 10.1038/s44318-024-00217-y
-
J Invest Dermatol, 2024, S0022-202X(23)03210-4
-
Cell Chem Biol, 2021, S2451-9456(21)00442-6
|
|
S4187 |
Salicylanilide
|
Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
-
Hum Mol Genet, 2020, ddaa244
|
|
S9057 |
Sinigrin
|
Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. |
-
J Invest Dermatol, 2018, 138(12):2644-2652
|
|
S5033 |
Terconazole
|
Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470) is a new, broad-spectrum, triazole antifungal agent which is primarily used to treat vaginal fungal infections. |
-
bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S5174 |
Kojic acid
|
Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
-
Int J Mol Sci, 2017, 18(9)
|
|
S3722 |
Isavuconazole
|
Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis. |
-
J Pharm Sci, 2023, 10.1016/j.xphs.2023.11.005
|
|
S5083 |
Lentinan
|
Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects. |
-
Cell Commun Signal, 2024, 22(1):376
-
Iran J Basic Med Sci, 2023, 26(7):836-842
|
|
S4878 |
Neticonazole Hydrochloride
|
Neticonazole is an imidazole antifungal for the treatment of fungal skin infections. |
-
Toxins (Basel), 2024, 16(9)380
-
Clin Transl Med, 2022, 12(9):e1037
|
|
S5512 |
Juglone
|
Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics.Solutions are unstable and should be fresh-prepared. |
-
Chin Med, 2024, 19(1):52
-
Nat Commun, 2019, 10(1):4013
|
|
S1997 |
Liranaftate
|
Liranaftate (M-732,Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. |
-
Cell Rep, 2024, 43(4):114094
|
|
S2031 |
Fenticonazole Nitrate
|
Fenticonazole Nitrate(Lomexin,REC 15-1476,Falvin) is an azole antifungal agent. |
|
|
S3154 |
Butenafine HCl
|
Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. |
|
|
S3156 |
Naftifine HCl
|
Naftifine(AW 105-843) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. |
-
Clin Transl Med, 2024, 14(2):e1586
-
Arch Biochem Biophys, 2024, 754:109958
|
|
S1833 |
Butoconazole nitrate
|
Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively). |
|
|
S4806 |
Potassium 1-Naphthaleneacetate
|
Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens. |
|
|
E3040 |
Stemonae Extract
|
Stemonae Extract is extracted from Radix Stemonae, has been widely used as an oral anti-tussive agent in traditional Chinese medicine (TCM) for thousands of years with pharmacological effects as anti-tussive, anti-tuberculous, anti-bacterial, anti-fungal and anti-helminthic. |
|
|
S9200 |
Pneumocandin B0
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
|
|
S0917 |
Allosecurinin
|
Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity. |
|
|
S6254 |
Hydrocinnamic acid
|
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite. |
|
|
S4581 |
Triacetin
|
Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) is a triglyceride that is used as an antifungal agent. |
|
|
S5213 |
Piroctone Olamine
|
Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections. |
|
|
S5553 |
Kasugamycin hydrochloride
|
Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species. |
|
|
S0938 |
Sakuranetin
|
Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. |
|
|
E3071 |
Malaytea Scurfpea Extract
|
Malaytea Scurfpea Extract is extracted from Psoralea corylifolia L., which has antifungal activity and acts as a defence against pathogens. |
|
|
S5944 |
Butenafine
|
Butenafine is a synthetic benzylamine antifungal agent. |
|
|
S3966 |
Nifuratel
|
Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action. |
|
|
S3307 |
Galangin 3-methyl ether
|
Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin), isolated from Lychnophora markgravii aerial parts, shows strong antibacterial and antifungal effects. |
|
|
S4970 |
Nerol
|
Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis. |
|
|
S4862 |
Squalene
|
Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response. |
-
Nature, 2024, 626(7998):411-418.
|
|
S3829 |
Isoalantolactone
|
Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent. |
|
|
S0770 |
Camalexin
|
Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. |
|
|
S6118 |
Terpinen-4-ol
|
Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties., |
|
|
S4996 |
Tavaborole (AN-2690)
|
Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity. |
|
|
S5271 |
Suloctidil
|
Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent. |
|
|
E3725 |
Sapindus saponaria Linnaeus nutshell Extract (40%)
|
Sapindus Saponaria Linnaeus Nutshell Extract (40%) is derived from Sapindus saponaria L., which has antifungal properties. |
|
|
E3726 |
Sapindus saponaria Linnaeus nutshell Extract (70%)
|
Sapindus Saponaria Linnaeus Nutshell Extract (70%) is derived from Sapindus saponaria L., which has antifungal properties. |
|
|
S4755 |
lanosterol
|
Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol. |
-
Commun Biol, 2023, 6(1):1108
|
|
S3532 |
AN-2718
|
AN-2718, an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism. |
|
|
S3778 |
Patchouli alcohol
|
Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis. |
|
|
S4963 |
Purpurin
|
Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin) is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. It exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. Purpurin strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1. |
|
|
S6270 |
2-Aminoisobutyric acid
|
2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH) is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. |
|
|
S4258 |
Luliconazole
|
Luliconazole(NND 502) is a broad-spectrum antifungal drug. |
-
Arch Biochem Biophys, 2024, 754:109958
|
|
S9350 |
Ethyl 4-Methoxycinnamate
|
Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. |
|
|
S2534 |
Isoconazole nitrate
|
Isoconazole nitrate (Travogen,Adestan G 100, R 15454) is an azole antifungal reagent. |
|
|
S5704 |
Myclobutanil
|
Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
|
|
S3705 |
Chlorobutanol
|
Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties. |
|
|
S1991 |
iKIX1
|
iKIX1 is an antifungal agent and resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, which blocks the interaction between the CgGal11A KIX domain and theCgPdr1 activation domain (AD), the IC50 and Ki values are 190.2 μM and 18 μM, respectively. |
|
|
S3860 |
Allicin
|
Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
|
|
S9072 |
Sweroside
|
Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
|
|
S6408 |
Hexetidine
|
Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity. |
|
|
S5025 |
Efinaconazole
|
Efinaconazole (KP-103) is an inhibitor of 14 alpha-demethylase which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. |
|
|
S3588 |
Hexylene glycol
|
Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) is an oxygenated solvent derived from acetone that has been used widely in industrial chemicals and cosmetics. Hexylene glycol exhibits antibacterial and antifungal properties. |
|
|
S3595 |
D-Gluconic acid
|
D-Gluconic acid is an antifungal agent. |
|
|
S9413 |
Yangonin
|
Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. |
|
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E3706 |
Cortex pseudolaricis Extract
|
Cortex Pseudolaricis Extract is derived from the root bark of Pseudolarix amabilis Rehder, of which some constituents possess biological activity such as antifungal activity, anticancer activity, and peroxisome proliferator-activated receptor activity. |
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S5724 |
Dichlorophen
|
Dichlorophen (Dichlorophene, Bis(5-chloro-2-hydroxyphenyl)methane) is an anticestodal agent, fungicide, germicide, and antimicrobial agent. |
-
Nat Commun, 2024, 15(1):8708
|
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S5829 |
Monomyristin
|
Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate), a monoacylglyceride, shows high antibacterial and antifungal activities. |
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S6451 |
Salifungin
|
Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals. |
|
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S5541 |
Dimetridazole
|
Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds. |
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S3979 |
Zinc Undecylenate
|
Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. |
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S5086 |
p-Anisaldehyde
|
p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices. |
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S6467 |
Fosfluconazole
|
Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
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S9444 |
Tomatine
|
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties. |
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S4525 |
Ethylparaben
|
Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. |
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S4781 |
Xanthoxyline
|
Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin. |
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S5845 |
Chalcone
|
Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones with antibacterial, antifungal, antitumor and anti-inflammatory properties. |
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S4793 |
Cedryl acetate
|
Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
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E3772 |
Eyebright Extract
|
Eyebright Extract is extracted from Herba Euphrasiae (Scrophulariaceae), which includes anti-inflammatory, antioxidant, antimicrobial, anticancer, antifungal, antiviral, hypotensive, hapatoprotector, anti-epileptic, and anti-catarrhal activities. |
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E3488 |
Fucus vesiculosis Extract
|
Fucus Vesiculosis Extract is extrcated from Fucus vesiculosus, which has antifungal properties. |
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S4516 |
(+)-Camphor
|
Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3. |
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S4843 |
Potassium acetate
|
Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties. |
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E4002 |
Potassium D-gluconate
|
Potassium D-gluconate(Potassium Gluconate) is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties. |
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S3910 |
4',7-Dimethoxyisoflavone
|
4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
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S4559 |
Cloxiquine
|
Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an antibacterial, antifungal, antiaging and antituberculosis drug. |
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S3985 |
Methyl 4-hydroxybenzoate
|
Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives. |
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S0491 |
Manogepix (E1210)
|
Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity. |
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S3990 |
Trans-Anethole
|
Trans-anethole (4-Propenylanisole) is a phenylpropene derivative found in many essential oils, including anise oil. It has neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities. |
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S7418 |
Cycloheximide
|
Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
- Signal Transduct Target Ther, 2024, 9(1):65
- Mol Cancer, 2024, 23(1):143
- Cell Metab, 2024, 36(7):1598-1618.e11
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S2476 |
Itraconazole
|
Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy. |
- Front Cell Infect Microbiol, 2023, 13:1128000
- Front Cell Infect Microbiol, 2023, 13:1131641
- Front Cell Infect Microbiol, 2022, 12:864912
|
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S1331 |
Fluconazole
|
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
- Front Cell Infect Microbiol, 2024, 14:1296151
- Front Cell Infect Microbiol, 2023, 13:1131641
- Nat Commun, 2022, 13(1):1658
|
|
S1353 |
Ketoconazole
|
Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor. |
- J Med Virol, 2023, 95(6):e28856
- J Med Virol, 2023, 95(6):e28856
- Cell Death Dis, 2023, 14(1):64
|
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S3073 |
Caspofungin (MK-0991) Acetate
|
Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor. |
- PLoS Pathog, 2024, 20(9):e1012521
- Viruses, 2023, 15(2)452
- BMC Med, 2022, 20(1):359
|
|
S1934 |
Nystatin
|
Nystatin(Fungicidin), which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis. |
- Microbiol Spectr, 2023, 10.1128/spectrum.02553-23
- Nature, 2022, 603(7899):159-165
- Nat Metab, 2022, 4-10:1369-1401
|
|
S4286 |
Anidulafungin
|
Anidulafungin, an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
|
- Viruses, 2023, 15(2)452
- BMC Med, 2022, 20(1):359
- Antiviral Res, 2021, S0166-3542(21)00178-9
|
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S4287 |
Micafungin Sodium
|
Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
|
- Microbiol Spectr, 2024, e0352623.
- BMC Med, 2022, 20(1):359
- Antiviral Res, 2021, S0166-3542(21)00178-9
|
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S3019 |
Ciclopirox ethanolamine
|
Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator. |
- Commun Biol, 2023, 6(1):402
- Commun Biol, 2023, 6(1):402
- J Clin Invest, 2022, 132(9)e152345
|
|
S2058 |
Tolnaftate
|
Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent. |
- J Pers Med, 2022, 12(2)258
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 34(6):1911-1918
|
|
S2321 |
Magnolol
|
Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation. |
- Mol Oncol, 2022, 16(15):2823-2842
- Int Immunopharmacol, 2022, 112:109242
- Reprod Biol, 2021, 21(4):100567
|
|
S1725 |
Terbinafine
|
Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth. |
- Front Oncol, 2023, 13:1111570
- Neurooncol Adv, 2022, 4(1):vdac018
- J Cell Mol Med, 2020, 25
|
|
S1956 |
Miconazole Nitrate
|
Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections. |
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
- Chem Biol Interact, 2021, 343:109498
- Biomol Ther (Seoul), 2020, 25
|
|
S2528 |
Ciclopirox
|
Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator. |
- Cell Death Dis, 2021, 12(12):1141
- J Transl Med, 2021, 19(1):347
- Int J Mol Sci, 2021, 22(15)8299
|
|
S3079 |
Atovaquone
|
Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. |
- Cells, 2024, 13(12)1025
- iScience, 2024, 27(3):109172
- J Cell Biochem, 2022, 10.1002/jcb.30213
|
|
S1606 |
Clotrimazole
|
Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections. |
- iScience, 2022, 25(11):105342
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
- J Cell Physiol, 2020, 10.1002
|
|
S2557 |
Terbinafine HCl
|
Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug. |
- Cell Rep Med, 2023, S2666-3791(22)00494-3
- Oncogene, 2021, 10.1038/s41388-021-01934-y
- J Cell Mol Med, 2020, 25
|
|
S2536 |
Miconazole
|
Miconazole (Monistat,R18134) is an imidazole antifungal agent. |
- Nat Commun, 2024, 15(1):3068
- Int J Mol Sci, 2022, 23(22)13809
- Chem Biol Interact, 2021, 343:109498
|
|
S1676 |
Amorolfine HCl
|
Amorolfine HCl(Ro 14-4767 HCl) is an antifungal reagent. |
- Nat Commun, 2021, 12(1):652
- Cell Chem Biol, 2019, 26(4):593-599
- Nature, 2018, 560(7718):372-376
|
|
S4075 |
Zinc Pyrithione
|
Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. |
- Cell Chem Biol, 2021, S2451-9456(21)00213-0
- Biol Reprod, 2019, 100(2):468-478
- Cell Syst, 2017, 4(6-:600-610
|
|
S5080 |
Neticonazole
|
Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity. |
- Nat Commun, 2023, 14(1):6692
- Nat Commun, 2023, 14(1):6692
- Clin Transl Med, 2022, 12(9):e1037
|
|
S1517 |
Natamycin
|
Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference |
- Expert Opin Drug Deliv, 2020, 17(3):407-421
- BMC Microbiol, 2020, 20(1):275
|
|
S2535 |
Econazole nitrate
|
Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus. |
- Nat Commun, 2024, 15(1):8708
- Cell Rep Med, 2023, 4(12):101309
- Int J Mol Sci, 2022, 23(22)13809
|
|
S1910 |
Tioconazole
|
Tioconazole (UK-20349) is an antifungal medication with an average IC50 of 1.7 μM. |
- J Mol Cell Biol, 2021, mjab059
- Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
|
|
S4120 |
Sulconazole Nitrate
|
Sulconazole Nitrate(Exelderm,RS 44872) is an imidazole derivative with broad-spectrum antifungal activity. |
- Int J Mol Sci, 2022, 23(22)13809
- Sci Adv, 2021, 7(36):eabf6033
|
|
S4601 |
Clioquinol
|
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. |
- Cancer Lett, 2024, 588:216797
- Mol Oncol, 2021, 10.1002/1878-0261.13079
- FASEB J, 2019, 10.1096/fj.201802603RR
|
|
S5373 |
Pseudolaric Acid B
|
Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties. |
- Toxicology, 2023, 493:153556
- Eur J Pharmacol, 2020, 876:173064
|
|
S1666 |
Flucytosine (5-Fluorocytosine)
|
Flucytosine (5-Fluorocytosine) is an antifungal drug with IC50 of 0.93 μM in C. albicans. |
- Sci Adv, 2021, 7(27)eabh3032
|
|
S1854 |
Bifonazole
|
Bifonazole (Bay h 4502,(±)-bifonazole) is a substituted imidazole antifungal agent. |
- Nature, 2018, 560(7718):372-376
|
|
S3161 |
Sertaconazole nitrate
|
Sertaconazole nitrate (FI-7045,FI7056) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections. |
- Int J Mol Sci, 2022, 23(22)13809
|
|
S5359 |
Butoconazole
|
Butoconazole is an imidazole antifungal used in gynecology. |
- Arch Biochem Biophys, 2024, 754:109958
- Nature, 2018, 560(7718):372-376
|
|
S8095 |
Tubercidin
|
Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities. |
- Mol Cell, 2020, 80(6):1104-1122.e9
|
|
S4584 |
Butylparaben
|
Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products. |
- Environ Toxicol, 2018, 33(4):436-445
|
|
S4178 |
Climbazole
|
Climbazole(BAY-e 6975) is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits. |
- Sci Adv, 2022, 8(49):eadd2191
|
|
S3646 |
Thimerosal
|
Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
- EMBO J, 2024, 10.1038/s44318-024-00217-y
- J Invest Dermatol, 2024, S0022-202X(23)03210-4
- Cell Chem Biol, 2021, S2451-9456(21)00442-6
|
|
S4187 |
Salicylanilide
|
Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
- Hum Mol Genet, 2020, ddaa244
|
|
S9057 |
Sinigrin
|
Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. |
- J Invest Dermatol, 2018, 138(12):2644-2652
|
|
S5033 |
Terconazole
|
Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470) is a new, broad-spectrum, triazole antifungal agent which is primarily used to treat vaginal fungal infections. |
- bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S3722 |
Isavuconazole
|
Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis. |
- J Pharm Sci, 2023, 10.1016/j.xphs.2023.11.005
|
|
S4878 |
Neticonazole Hydrochloride
|
Neticonazole is an imidazole antifungal for the treatment of fungal skin infections. |
- Toxins (Basel), 2024, 16(9)380
- Clin Transl Med, 2022, 12(9):e1037
|
|
S5512 |
Juglone
|
Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics.Solutions are unstable and should be fresh-prepared. |
- Chin Med, 2024, 19(1):52
- Nat Commun, 2019, 10(1):4013
|
|
S1997 |
Liranaftate
|
Liranaftate (M-732,Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. |
- Cell Rep, 2024, 43(4):114094
|
|
S2031 |
Fenticonazole Nitrate
|
Fenticonazole Nitrate(Lomexin,REC 15-1476,Falvin) is an azole antifungal agent. |
|
|
S3154 |
Butenafine HCl
|
Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. |
|
|
S3156 |
Naftifine HCl
|
Naftifine(AW 105-843) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. |
- Clin Transl Med, 2024, 14(2):e1586
- Arch Biochem Biophys, 2024, 754:109958
|
|
S1833 |
Butoconazole nitrate
|
Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively). |
|
|
S4806 |
Potassium 1-Naphthaleneacetate
|
Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens. |
|
|
E3040 |
Stemonae Extract
|
Stemonae Extract is extracted from Radix Stemonae, has been widely used as an oral anti-tussive agent in traditional Chinese medicine (TCM) for thousands of years with pharmacological effects as anti-tussive, anti-tuberculous, anti-bacterial, anti-fungal and anti-helminthic. |
|
|
S9200 |
Pneumocandin B0
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
|
|
S0917 |
Allosecurinin
|
Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity. |
|
|
S6254 |
Hydrocinnamic acid
|
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite. |
|
|
S4581 |
Triacetin
|
Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) is a triglyceride that is used as an antifungal agent. |
|
|
S5213 |
Piroctone Olamine
|
Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections. |
|
|
S5553 |
Kasugamycin hydrochloride
|
Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species. |
|
|
S0938 |
Sakuranetin
|
Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. |
|
|
E3071 |
Malaytea Scurfpea Extract
|
Malaytea Scurfpea Extract is extracted from Psoralea corylifolia L., which has antifungal activity and acts as a defence against pathogens. |
|
|
S5944 |
Butenafine
|
Butenafine is a synthetic benzylamine antifungal agent. |
|
|
S3966 |
Nifuratel
|
Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action. |
|
|
S3307 |
Galangin 3-methyl ether
|
Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin), isolated from Lychnophora markgravii aerial parts, shows strong antibacterial and antifungal effects. |
|
|
S4970 |
Nerol
|
Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis. |
|
|
S3829 |
Isoalantolactone
|
Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent. |
|
|
S0770 |
Camalexin
|
Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. |
|
|
S6118 |
Terpinen-4-ol
|
Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties., |
|
|
S4996 |
Tavaborole (AN-2690)
|
Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity. |
|
|
S5271 |
Suloctidil
|
Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent. |
|
|
E3725 |
Sapindus saponaria Linnaeus nutshell Extract (40%)
|
Sapindus Saponaria Linnaeus Nutshell Extract (40%) is derived from Sapindus saponaria L., which has antifungal properties. |
|
|
E3726 |
Sapindus saponaria Linnaeus nutshell Extract (70%)
|
Sapindus Saponaria Linnaeus Nutshell Extract (70%) is derived from Sapindus saponaria L., which has antifungal properties. |
|
|
S4755 |
lanosterol
|
Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol. |
- Commun Biol, 2023, 6(1):1108
|
|
S3532 |
AN-2718
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AN-2718, an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism. |
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S3778 |
Patchouli alcohol
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Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis. |
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S4963 |
Purpurin
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Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin) is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. It exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities. Purpurin strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1. |
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S6270 |
2-Aminoisobutyric acid
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2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH) is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. |
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S4258 |
Luliconazole
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Luliconazole(NND 502) is a broad-spectrum antifungal drug. |
- Arch Biochem Biophys, 2024, 754:109958
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S9350 |
Ethyl 4-Methoxycinnamate
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Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. |
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S2534 |
Isoconazole nitrate
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Isoconazole nitrate (Travogen,Adestan G 100, R 15454) is an azole antifungal reagent. |
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S5704 |
Myclobutanil
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Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
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S3705 |
Chlorobutanol
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Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties. |
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S1991 |
iKIX1
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iKIX1 is an antifungal agent and resensitizes drug-resistant Candida glabrata to azole antifungals in vitro, which blocks the interaction between the CgGal11A KIX domain and theCgPdr1 activation domain (AD), the IC50 and Ki values are 190.2 μM and 18 μM, respectively. |
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S3860 |
Allicin
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Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
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S9072 |
Sweroside
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Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
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S6408 |
Hexetidine
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Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity. |
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S5025 |
Efinaconazole
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Efinaconazole (KP-103) is an inhibitor of 14 alpha-demethylase which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. |
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S3588 |
Hexylene glycol
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Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) is an oxygenated solvent derived from acetone that has been used widely in industrial chemicals and cosmetics. Hexylene glycol exhibits antibacterial and antifungal properties. |
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S3595 |
D-Gluconic acid
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D-Gluconic acid is an antifungal agent. |
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S9413 |
Yangonin
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Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. |
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E3706 |
Cortex pseudolaricis Extract
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Cortex Pseudolaricis Extract is derived from the root bark of Pseudolarix amabilis Rehder, of which some constituents possess biological activity such as antifungal activity, anticancer activity, and peroxisome proliferator-activated receptor activity. |
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S5724 |
Dichlorophen
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Dichlorophen (Dichlorophene, Bis(5-chloro-2-hydroxyphenyl)methane) is an anticestodal agent, fungicide, germicide, and antimicrobial agent. |
- Nat Commun, 2024, 15(1):8708
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S5829 |
Monomyristin
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Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate), a monoacylglyceride, shows high antibacterial and antifungal activities. |
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S6451 |
Salifungin
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Salifungin (Multifungin, Bromosalicylchloranilide) is an antifungal and may cause allergic contact dermatitis in some individuals. |
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S5541 |
Dimetridazole
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Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds. |
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S3979 |
Zinc Undecylenate
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Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. |
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S5086 |
p-Anisaldehyde
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p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices. |
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S6467 |
Fosfluconazole
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Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
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S9444 |
Tomatine
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Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties. |
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S4525 |
Ethylparaben
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Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. It is a standardized chemical allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. |
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S5845 |
Chalcone
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Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones with antibacterial, antifungal, antitumor and anti-inflammatory properties. |
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S4793 |
Cedryl acetate
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Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
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E3772 |
Eyebright Extract
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Eyebright Extract is extracted from Herba Euphrasiae (Scrophulariaceae), which includes anti-inflammatory, antioxidant, antimicrobial, anticancer, antifungal, antiviral, hypotensive, hapatoprotector, anti-epileptic, and anti-catarrhal activities. |
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E3488 |
Fucus vesiculosis Extract
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Fucus Vesiculosis Extract is extrcated from Fucus vesiculosus, which has antifungal properties. |
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S4516 |
(+)-Camphor
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Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3. |
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S4843 |
Potassium acetate
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Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties. |
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S3910 |
4',7-Dimethoxyisoflavone
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4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
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S4559 |
Cloxiquine
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Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an antibacterial, antifungal, antiaging and antituberculosis drug. |
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S3985 |
Methyl 4-hydroxybenzoate
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Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives. |
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S0491 |
Manogepix (E1210)
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Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity. |
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S3990 |
Trans-Anethole
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Trans-anethole (4-Propenylanisole) is a phenylpropene derivative found in many essential oils, including anise oil. It has neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities. |
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