S3732 |
Avibactam sodium
|
Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively. |
-
ACS Infect Dis, 2023, 10.1021/acsinfecdis.3c00264
-
Microbiol Spectr, 2022, 10(5):e0115922
-
J Glob Antimicrob Resist, 2021, 28:49-52
|
|
S4042 |
Nafcillin Sodium
|
Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM. |
|
|
S2551 |
Sulbactam sodium
|
Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor. |
|
|
S5411 |
Sultamicillin
|
Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester. |
|
|
E4985New |
Avibactam sodium hydrate
|
Avibactam sodium hydrate(NXL-104 hydrate) is a covalent and reversible non-β-lactam inhibitor of β-lactamase which inhibits β-lactamase activity with IC50 values of 8 nM for TEM-1 and 5 nM for CTX-M-15, respectively. |
|
|
E4820New |
Sulbactam pivoxil
|
Sulbactam pivoxil (CP 47904), a proagent of sulbactam, is an inhibitor of β-lactamase. Sulbactam pivoxil provides higher absorption than its parent compound and achieves high serum levels following oral administration. |
|
|
E4984New |
Avibactam free acid
|
Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections. |
|
|
E4465 |
Potassium clavulanate cellulose
|
Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. |
|
|
E0167 |
Tazobactam Sodium
|
Tazobactam (Tazobactam acid, Tazobactamum) Sodium is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms.
|
|
|
E4472 |
Clavulanic acid
|
Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin. |
|
|
S0074 |
Relebactam
|
Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases. |
|
|
E4838New |
Cefuroxime
|
Cefuroxime (Kefurox) is an orally active, second-generation, broad-spectrum cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime exhibits broad-spectrum activity against Gram-positive bacteria including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria. |
|
|
S4620 |
Cefuroxime sodium
|
Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase. |
|
|
S3077 |
Tazobactam
|
Tazobactam (Tazobactam acid, Tazobactamum) is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect. |
-
Antimicrob Resist Infect Control, 2024, 13(1):91
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
BMC Pharmacol Toxicol, 2024, 25(1):25
|
|
E4810New |
Piperacillin
|
Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins. |
|
|
S3667 |
Imipenem
|
Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections. |
|
|
S4111 |
Dicloxacillin Sodium
|
Dicloxacillin Sodium (Veracillin, BRL1702) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria. |
|
|
S3732 |
Avibactam sodium
|
Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively. |
- ACS Infect Dis, 2023, 10.1021/acsinfecdis.3c00264
- Microbiol Spectr, 2022, 10(5):e0115922
- J Glob Antimicrob Resist, 2021, 28:49-52
|
|
S4042 |
Nafcillin Sodium
|
Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM. |
|
|
S2551 |
Sulbactam sodium
|
Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor. |
|
|
S5411 |
Sultamicillin
|
Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester. |
|
|
E4985New |
Avibactam sodium hydrate
|
Avibactam sodium hydrate(NXL-104 hydrate) is a covalent and reversible non-β-lactam inhibitor of β-lactamase which inhibits β-lactamase activity with IC50 values of 8 nM for TEM-1 and 5 nM for CTX-M-15, respectively. |
|
|
E4820New |
Sulbactam pivoxil
|
Sulbactam pivoxil (CP 47904), a proagent of sulbactam, is an inhibitor of β-lactamase. Sulbactam pivoxil provides higher absorption than its parent compound and achieves high serum levels following oral administration. |
|
|
E4984New |
Avibactam free acid
|
Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections. |
|
|
E4465 |
Potassium clavulanate cellulose
|
Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. |
|
|
E0167 |
Tazobactam Sodium
|
Tazobactam (Tazobactam acid, Tazobactamum) Sodium is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms.
|
|
|
E4472 |
Clavulanic acid
|
Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin. |
|
|
S0074 |
Relebactam
|
Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases. |
|
|
S4620 |
Cefuroxime sodium
|
Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase. |
|
|
S3077 |
Tazobactam
|
Tazobactam (Tazobactam acid, Tazobactamum) is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect. |
- Antimicrob Resist Infect Control, 2024, 13(1):91
- BMC Pharmacol Toxicol, 2024, 25(1):25
- BMC Pharmacol Toxicol, 2024, 25(1):25
|
|
E4810New |
Piperacillin
|
Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins. |
|
|
S3667 |
Imipenem
|
Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections. |
|
|
S4111 |
Dicloxacillin Sodium
|
Dicloxacillin Sodium (Veracillin, BRL1702) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria. |
|
|
E4985New |
Avibactam sodium hydrate
|
Avibactam sodium hydrate(NXL-104 hydrate) is a covalent and reversible non-β-lactam inhibitor of β-lactamase which inhibits β-lactamase activity with IC50 values of 8 nM for TEM-1 and 5 nM for CTX-M-15, respectively. |
|
|
E4820New |
Sulbactam pivoxil
|
Sulbactam pivoxil (CP 47904), a proagent of sulbactam, is an inhibitor of β-lactamase. Sulbactam pivoxil provides higher absorption than its parent compound and achieves high serum levels following oral administration. |
|
|
E4984New |
Avibactam free acid
|
Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections. |
|
|
E4838New |
Cefuroxime
|
Cefuroxime (Kefurox) is an orally active, second-generation, broad-spectrum cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime exhibits broad-spectrum activity against Gram-positive bacteria including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria. |
|
|
E4810New |
Piperacillin
|
Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins. |
|
|