Home Microbiology β-lactamase inhibitor Avibactam sodium For research use only.

Avibactam sodium

Synonyms: AVE-1330A, NXL104

Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.

Avibactam sodium Chemical Structure

Avibactam sodium Chemical Structure

CAS No. 1192491-61-4

Purity & Quality Control

Avibactam sodium Related Products

Biological Activity

Description Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.
Targets
SHV-4 [1]
(Cell-free assay)		 TEM-1 [1]
(Cell-free assay)		 KPC-2 [1]
(Cell-free assay)		 P99 [1]
(Cell-free assay)
1.5 nM 8 nM 38 nM 80 nM
In vitro
In vitro Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D enzymes[1]. Avibactam has an unusual mechanism of action: it is a covalent inhibitor that acts via ring opening, but in contrast to other currently used β-lactamase inhibitors, this reaction is reversible[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01448395 Completed
Healthy
Pfizer
 October 2011 Phase 1
NCT01291602 Completed
Healthy Male and Female Japanese Volunteers
Pfizer
 February 2011 Phase 1

Chemical Information & Solubility

Molecular Weight 287.23 Formula

C7H10N3O6 .Na
CAS No. 1192491-61-4 SDF Download Avibactam sodium SDF
Smiles C1CC(N2CC1N(C2=O)OS(=O)(=O)[O-])C(=O)N.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 57 mg/mL ( (198.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 57 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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