Home Microbiology β-lactamase inhibitor Clavulanic acid For research use only.

Clavulanic acid

Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin.

Clavulanic acid Chemical Structure

Clavulanic acid Chemical Structure

CAS No. 58001-44-8

Purity & Quality Control

Batch: E447201 DMSO]40 mg/mL]false]Water]40 mg/mL]false]Ethanol]2 mg/mL]false Purity: 99.79%
99.79

Clavulanic acid Related Products

Biological Activity

Description Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin.
Targets
β-lactamase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05584683 Recruiting
Pediatric|Bacterial Infections
Kaizen Bioscience Co.
 August 9 2023 Phase 1
NCT05340257 Not yet recruiting
Infections Bacterial
GlaxoSmithKline
 June 23 2023 Phase 2
NCT05562349 Active not recruiting
Cocaine Dependence
Temple University|University of Pennsylvania|Medical University of South Carolina|Research Foundation for Mental Hygiene Inc.
 May 3 2023 Phase 2
NCT03702894 Completed
Bioequivalence
Pharmtechnology LLC|ClinPharmInvest LLC
 September 21 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 199.16 Formula

C8H9NO5
CAS No. 58001-44-8 SDF Download Clavulanic acid SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (200.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 40 mg/mL

Ethanol : 2 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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