Home Microbiology Fungal inhibitor Thimerosal

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Thimerosal Fungal inhibitor

Cat.No.S3646

Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Thimerosal Fungal inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 404.81

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Quality Control

Batch: S364601 DMSO]80 mg/mL]false]Water]80 mg/mL]false]Ethanol]20 mg/mL]false Purity: 98.31%
98.31

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (197.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 80 mg/mL

Ethanol : 20 mg/mL

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 404.81 Formula

C9H9HgO2S.Na

 Storage (From the date of receipt)
CAS No. 54-64-8 Download SDF Storage of Stock Solutions

Synonyms Thiomersalate, Mercurothiolate SMILES CC[Hg]SC1=CC=CC=C1C(=O)[O-].[Na+]

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro
The treatment of Jurkat T cells with thimerosal causes a significant decrease in cellular viability at 1 μM (25%, p<0.05; IC50: 10 μM). Thimerosal is also able to induce apoptosis and G2/M phase in human leukemia U937 cells.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2021-04-13)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04522830 COMPLETED
SARS-CoV-2 Infection
Beech Tree Labs, Inc.
 2020-07-30 PHASE2
NCT00980005 COMPLETED
Influenza
GlaxoSmithKline
 2009-10-13 PHASE3
NCT00778895 COMPLETED
Influenza
GlaxoSmithKline
 2008-11-10 PHASE2
NCT00764790 COMPLETED
Influenza
GlaxoSmithKline
 2008-10-01 PHASE3
NCT00612768 COMPLETED
Dermatitis, Contact
Allerderm
 2008-01 PHASE2
NCT00795951 Completed
Dermatitis Contact
Allerderm
 2008-11 Phase 4

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