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Vernakalant (RSD1235) Hydrochloride
Synonyms: MK-6621
Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.
Vernakalant (RSD1235) Hydrochloride Chemical Structure
CAS No. 748810-28-8
Purity & Quality Control
Vernakalant (RSD1235) Hydrochloride Related Products
| Related Targets | Ca2+-dependent K+ channel | Click to Expand |
|---|---|---|
| Related Products | Nicorandil TRAM-34 Sophocarpine ML133 HCl Hydralazine HCl Gliquidone PAP-1 | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Ion Channel Ligand Library Exosome Secretion Related Compound Library Calcium Channel Blocker Library | Click to Expand |
Signaling Pathway
Biological Activity
| Description | Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period. |
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|---|---|---|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00125320 | Completed | Atrial Fibrillation|Atrial Flutter |
Astellas Pharma Inc|Astellas Pharma US Inc.|Advanz Pharma |
June 2004 | Phase 3 |
| NCT00115791 | Completed | Atrial Flutter|Atrial Fibrillation |
Astellas Pharma Inc|Advanz Pharma |
June 2004 | Phase 3 |
| NCT00476112 | Completed | Atrial Flutter |
Advanz Pharma|Astellas Pharma US Inc. |
August 2003 | Phase 2|Phase 3 |
| NCT00468767 | Completed | Atrial Fibrillation |
Advanz Pharma|Astellas Pharma US Inc. |
August 2003 | Phase 3 |
Chemical Information & Solubility
| Molecular Weight | 385.93 | Formula | C20H31NO4.ClH |
| CAS No. | 748810-28-8 | SDF | -- |
| Smiles | Cl.COC1=C(OC)C=C(CCOC2CCCCC2N3CCC(O)C3)C=C1 | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 77 mg/mL ( (199.51 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Water : 77 mg/mL Ethanol : 77 mg/mL |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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