Home Neuronal Signaling COX inhibitor Trometamol For research use only.

Trometamol

Synonyms: Tromethamine

Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.

Trometamol Chemical Structure

Trometamol Chemical Structure

CAS No. 77-86-1

Purity & Quality Control

Batch: S417601 Water]24 mg/mL]false]DMSO]2 mg/mL]false]Ethanol]Insoluble]false Purity: 100.0%
100.0

Trometamol Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.
Targets
proton acceptor [1]
In vitro
In vitro

Trometamol is a proton acceptor that generates NH3 +/HCO3 - without generating CO2, and the protonated R-NH3 + is eliminated by the kidneys. Trometamol is the buffer of choice in the situation where CO2 elimination is impaired (in which case NaHCO3 cannot correct acidemia), and to avoid a Na+ load. Even during short intervals of apneic oxygenation when CO2 elimination is curtailed, trometamol, but not bicarbonate, will maintain a normal arterial pH. Trometamol also acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide and electrolytes. A significant fraction of trometamol is not ionized and therefore is capable of reaching equilibrium in total body water. This portion may penetrate cells and may neutralize acidic ions of the intracellular fluid. [1]
In Vivo
In vivo

The drug is rapidly eliminated by the kidney; 75% or more appears in the urine after eight hours. Urinary excretion continues over a period of three days. The maximum daily dose is 15 mmol/kg for an adult. In large doses, trometamol may induce respiratory depression and hypoglycemia. [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02086097 Completed
Irreversible Pulpitis
Daniel Chavarría Bolaños|Universidad Autonoma de San Luis Potosí
 August 2013 Phase 4
NCT01365611 Completed
Healthy Subjects
Egalet Ltd
 February 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 121.14 Formula

C4H11NO3
CAS No. 77-86-1 SDF Download Trometamol SDF
Smiles C(C(CO)(CO)N)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 24 mg/mL

DMSO : 2 mg/mL ( (16.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Trometamol | Trometamol ic50 | Trometamol price | Trometamol cost | Trometamol solubility dmso | Trometamol purchase | Trometamol manufacturer | Trometamol research buy | Trometamol order | Trometamol mouse | Trometamol chemical structure | Trometamol mw | Trometamol molecular weight | Trometamol datasheet | Trometamol supplier | Trometamol in vitro | Trometamol cell line | Trometamol concentration | Trometamol nmr