Home Angiogenesis BTK inhibitor M7583 For research use only.

M7583

Synonyms: TL-895

M7583 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.

M7583 Chemical Structure

M7583 Chemical Structure

CAS No. 1415823-49-2

Purity & Quality Control

Batch: E283801 DMSO]90 mg/mL]false]Ethanol]22 mg/mL]false]Water]Insoluble]false Purity: 99.82%
99.82

M7583 Related Products

Signaling Pathway

BTK Signaling Pathways

BTK Signaling Pathway

Biological Activity

Description M7583 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.
Targets
BTK [1] BTK [1]
1.5 nM 11.9 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05280509 Recruiting
Myelofibrosis|Primary Myelofibrosis|Post-PV MF|Post-ET Myelofibrosis
Telios Pharma Inc.
 June 9 2022 Phase 1|Phase 2
NCT04669067 Active not recruiting
Acute Myeloid Leukemia
Telios Pharma Inc.|Kartos Therapeutics Inc.
 March 31 2021 Phase 1|Phase 2
NCT04640532 Recruiting
Myelofibrosis|Post-PV MF|Post-ET Myelofibrosis|Primary Myelofibrosis
Kartos Therapeutics Inc.|Telios Pharma Inc.
 November 17 2020 Phase 1|Phase 2
NCT04655118 Recruiting
Myelofibrosis|Indolent Systemic Mastocytosis
Telios Pharma Inc.
 October 22 2020 Phase 2
NCT04419623 Completed
COVID-19|Sars-CoV2|Cancer|Solid Tumor|Carcinoma|Blood Cancer
Telios Pharma Inc.
 July 9 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 447.51 Formula

C25H26FN5O2
CAS No. 1415823-49-2 SDF --
Smiles NC1=C(C(=NC=N1)NCC2(F)CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (201.11 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 22 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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