Home Cell Cycle Aurora Kinase inhibitor - FGFR inhibitor - VEGFR inhibitor - JAK inhibitor - CSF-1R inhibitor Tinengotinib For research use only.

Tinengotinib

Synonyms: TT-00420

Tinengotinib (TT-00420) is a novel multiple kinase inhibitor that strongly inhibits Aurora A/B with IC50 values of 1.2/3.3 nM respectively. It also exhibits potent inhibitory activity on FGFR1/2/3, VEGFR1, JAK1/2, and CSF1R and can be used to treat several prominent signaling pathways in triple-negative breast cancer(TNBC).

Tinengotinib Chemical Structure

Tinengotinib Chemical Structure

CAS No. 2230490-29-4

Purity & Quality Control

Batch: E143501 DMSO]79 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.07%
99.07

Tinengotinib Related Products

Signaling Pathway

Aurora Kinase Signaling Pathways

Aurora Kinase Signaling Pathway

Biological Activity

Description Tinengotinib (TT-00420) is a novel multiple kinase inhibitor that strongly inhibits Aurora A/B with IC50 values of 1.2/3.3 nM respectively. It also exhibits potent inhibitory activity on FGFR1/2/3, VEGFR1, JAK1/2, and CSF1R and can be used to treat several prominent signaling pathways in triple-negative breast cancer(TNBC).
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04919642 Completed
Cholangiocarcinoma|FGFR2 Fusion|FGFR2 Gene Mutation|FGFR1 Alteration|FGFR3 Alteration
TransThera Sciences (Nanjing) Inc.
 December 7 2021 Phase 2
NCT04705922 Completed
Healthy
TransThera Sciences (Nanjing) Inc.
 December 29 2020 Phase 1
NCT03654547 Active not recruiting
Advanced Solid Tumors|Triple Negative Breast Cancer
TransThera Sciences (Nanjing) Inc.
 January 8 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 394.86 Formula

C20H19ClN6O
CAS No. 2230490-29-4 SDF Download Tinengotinib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (200.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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