Home Neuronal Signaling 5-HT Receptor inhibitor Tafamidis For research use only.

Tafamidis

Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.

Tafamidis Chemical Structure

Tafamidis Chemical Structure

CAS No. 594839-88-0

Purity & Quality Control

Tafamidis Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06086353 Recruiting
Transthyretin Amyloid Cardiomyopathy
Pfizer
 March 25 2024 --
NCT05938218 Not yet recruiting
Amyloidosis Cardiac|Virtual Reality
Heinrich-Heine University Duesseldorf
 December 1 2023 Not Applicable
NCT05489523 Recruiting
Transthyretin Cardiac Amyloidosis
University of Texas Southwestern Medical Center
 May 1 2023 Phase 4
NCT05560555 Completed
Hereditary Transthyretin Amyloidosis (ATTRv)|Polyneuropathy
Pfizer
 October 24 2022 --
NCT05374564 Recruiting
Cardiomyopathies Primary
Yale University|Pfizer
 August 16 2022 Phase 1
NCT04814186 Completed
Transthyretin Amyloid Cardiomyopathy
Pfizer
 July 22 2021 Phase 4

Chemical Information & Solubility

Molecular Weight 308.12 Formula

C14H7Cl2NO3
CAS No. 594839-88-0 SDF --
Smiles C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 31 mg/mL ( (100.61 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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