Home Metabolism ROR agonist SR3335 For research use only.

SR3335

Synonyms: ML-176

SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.

SR3335 Chemical Structure

SR3335 Chemical Structure

CAS No. 293753-05-6

Purity & Quality Control

Batch: S296901 DMSO]81 mg/mL]false]Ethanol]81 mg/mL]false]Water]Insoluble]false Purity: 99.83%
99.83

SR3335 Related Products

Biological Activity

Description SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
Targets
RORα [1]
(Cell-free assay)
220 nM(Ki)
In vitro
In vitro

SR3335 (ML-176), a selective RORα synthetic ligand, directly binds to RORα, and functions as a selective partial inverse agonist of RORα, also suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.[1]
Cell Research Cell lines HEK293 cells
Concentrations 5 μM
Incubation Time --
Method

--
In Vivo
In vivo

SR3335 (ML-176) suppresses gluconeogenesis in diet-induced obesity (DIO) mouse model consistent with suppression of gluconeogenesis.[1]
Animal Research Animal Models diet induced obese (DIO) mice (C57Bl/6)
Dosages 15 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 405.34 Formula

C13H9F6NO3S2
CAS No. 293753-05-6 SDF --
Smiles OC(C1=CC=C(N[S](=O)(=O)C2=CC=CS2)C=C1)(C(F)(F)F)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 81 mg/mL ( (199.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 81 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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