SR3335

Catalog No.S2969 Batch:S296901

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Technical Data

Formula

C13H9F6NO3S2
Molecular Weight 405.34 CAS No. 293753-05-6
Solubility (25°C)* In vitro DMSO 81 mg/mL (199.83 mM)
Ethanol 81 mg/mL (199.83 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
Targets
RORα [1]
(Cell-free assay)
220 nM(Ki)
In vitro

SR3335 (ML-176), a selective RORα synthetic ligand, directly binds to RORα, and functions as a selective partial inverse agonist of RORα, also suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.[1]
In vivo

SR3335 (ML-176) suppresses gluconeogenesis in diet-induced obesity (DIO) mouse model consistent with suppression of gluconeogenesis.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HEK293 cells

  • Concentrations

    5 μM

  • Incubation Time

    --

  • Method

    --
Animal Study:

[1]
  • Animal Models

    diet induced obese (DIO) mice (C57Bl/6)

  • Dosages

    15 mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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