Home Transmembrane Transporters ROR agonist SR1078 For research use only.

SR1078

SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.

SR1078 Chemical Structure

SR1078 Chemical Structure

CAS No. 1246525-60-9

Purity & Quality Control

SR1078 Related Products

Biological Activity

Description SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
Targets
RORα [1] RORγ [1]
In vitro
In vitro SR1078 modulates the conformation of RORγ in a biochemical assay and activates RORα and RORγ driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both RORα and RORγ[1].
Cell Research Cell lines HepG2 cells
Concentrations 10 μM
Incubation Time 24 h
Method

--
In Vivo
In vivo SR1078 displays pharmacokinetic properties that allow it to be used in vivo[1].
Animal Research Animal Models C57BL6 mice
Dosages 10 mg/kg
Administration I.P.

Chemical Information & Solubility

Molecular Weight 431.25 Formula

C17H10F9NO2
CAS No. 1246525-60-9 SDF --
Smiles C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 86 mg/mL ( (199.42 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 86 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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