Home Immunology & Inflammation STING agonist SR-717 lithium For research use only.

SR-717 lithium

SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.

SR-717 lithium Chemical Structure

SR-717 lithium Chemical Structure

CAS No. 2375421-09-1

Purity & Quality Control

SR-717 lithium Related Products

Biological Activity

Description SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Targets
STING [1]
(in ISG-THP1 (WT) cells)		 STING [1]
(in ISG-THP1 (cGAS KO) cells)
2.1 μM(EC50) 2.2 μM(EC50)
In vitro
In vitro

SR-717 induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.[1]
Cell Research Cell lines ISG-THP1 STING KO cell lines
Concentrations 3.8 μM
Incubation Time 4 h
Method

"Western blot analyses the impact of SR-717 delivery (3.8 mM) on PD-L1 expression in WT THP1 or ISG-THP1 STING KO (STING KO) cells."
In Vivo
In vivo

SR-717 ( intraperitoneally for 7 days) displays antitumor activity in WT or Stinggt/gt mice; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.

Chemical Information & Solubility

Molecular Weight 351.19 Formula

C15H8F2LiN5O3
CAS No. 2375421-09-1 SDF --
Smiles [Li]OC(=O)C1=C(NC(=O)C2=NN=C(C=C2)[N]3C=CN=C3)C=C(F)C(=C1)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 20 mg/mL ( (56.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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