SR-717 lithium

Catalog No.S0853 Batch:S085302

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Technical Data

Formula

C15H8F2LiN5O3
Molecular Weight 351.19 CAS No. 2375421-09-1
Solubility (25°C)* In vitro DMSO 35 mg/mL (99.66 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Targets
STING [1]
(in ISG-THP1 (WT) cells)		 STING [1]
(in ISG-THP1 (cGAS KO) cells)
2.1 μM(EC50) 2.2 μM(EC50)
In vitro

SR-717 induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.[1]
In vivo

SR-717 ( intraperitoneally for 7 days) displays antitumor activity in WT or Stinggt/gt mice; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    ISG-THP1 STING KO cell lines

  • Concentrations

    3.8 μM

  • Incubation Time

    4 h

  • Method

    "Western blot analyses the impact of SR-717 delivery (3.8 mM) on PD-L1 expression in WT THP1 or ISG-THP1 STING KO (STING KO) cells."

Selleck's SR-717 lithium has been cited by 4 publications

Targeted Delivery of STING Agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive Cancers [ Pharmaceutics, 2024, 16(9)1216] PubMed: 39339252
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy [ Mol Neurobiol, 2022, 59(11):7006-7024] PubMed: 36070120
Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats [ J Inflamm Res, 2022, 15:5103-5119] PubMed: 36091334
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection [ Signal Transduct Target Ther, 2021, 6(1):382] PubMed: 34732709

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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