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Squalene

Synonyms: Spinacene, Supraene, trans-Squalene

Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.

Squalene Chemical Structure

Squalene Chemical Structure

CAS No. 111-02-4

Purity & Quality Control

Squalene Related Products

Biological Activity

Description Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.
In vitro
In vitro Squalene is a triterpene that is an intermediate in the cholesterol biosynthesis pathway. In vitro experimental evidence indicates that squalene is a highly effective oxygen-scavenging agent and possesses antioxidant properties[1].
In Vivo
In vivo Squalene appears to be critical in reducing free radical oxidative damage to the skin. It can effectively inhibit chemically induced skin tumorigenesis in rodents[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04555044 Completed
Essential Fatty Acid Deficiency (EFAD)
Baxter Healthcare Corporation
 January 22 2021 Phase 4
NCT03563222 Terminated
Malnutrition Child
Fresenius Kabi
 December 18 2019 Phase 4
NCT02476994 Terminated
Essential Fatty Acid Deficiency (EFAD)
Baxter Healthcare Corporation
 May 2015 Phase 4
NCT01902394 Completed
Digestive Health and Immune Function
Tufts University|General Mills|Tufts Medical Center
 June 2012 Not Applicable

Chemical Information & Solubility

Molecular Weight 410.72 Formula

C30H50
CAS No. 111-02-4 SDF --
Density 0.858 g/mL at 25 °C
Smiles CC(=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC=C(C)C)C)C)C
Storage (From the date of receipt) 2 years -80°C liquid

In vitro
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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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