Home Microbiology Antibiotics chemical Spiramycin For research use only.

Spiramycin

Synonyms: Formacidine

Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).

Spiramycin Chemical Structure

Spiramycin Chemical Structure

CAS: 8025-81-8

Selleck's Spiramycin has been cited by 1 publication

Purity & Quality Control

Batch: Purity: >97%
97

Spiramycin Related Products

Choose Selective Antibiotics Inhibitors

Biological Activity

Description Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
In vitro
In vitro Spiramycin reduces the hygromycin A protections of nucleotides in 23 S rRNA. [1] Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. Spiramycin acts primarily by stimulating the dissociation of peptidyl-tRNA from ribosomes during translocation. [2] Spiramycin at doses sufficient to inhibit protein synthesis in wild-type cells but not sufficient to kill either mutant or wild-type cells at the permissive temperature (30 degrees C). Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. [3] Spiramycin shows dose-related inhibition of the proliferative response of PHA and PWM stimulated human mononuclear leucocytes (MNL). Spiramycin also induces a decrease in tritiated uridine (3H-UdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle. [4] Spiramycin and, to a lesser extent, erythromycin increases total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide. [5] Spiramycin shows good antimicrobial activity against species of Prevotella, Eubacterium, Peptostreptococcus, Bacteroides and Porphyromonas, and the effect is enhanced by the addition of Metronidazole. [6]

Chemical Information & Solubility

Molecular Weight 843.05 Formula

C43H74N2O14
CAS No. 8025-81-8 SDF Download Spiramycin SDF
Smiles CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (118.61 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Spiramycin | Spiramycin ic50 | Spiramycin price | Spiramycin cost | Spiramycin solubility dmso | Spiramycin purchase | Spiramycin manufacturer | Spiramycin research buy | Spiramycin order | Spiramycin mouse | Spiramycin chemical structure | Spiramycin mw | Spiramycin molecular weight | Spiramycin datasheet | Spiramycin supplier | Spiramycin in vitro | Spiramycin cell line | Spiramycin concentration | Spiramycin nmr