Home Microbiology Antibiotics chemical Nanchangmycin For research use only.

Nanchangmycin

Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.

Nanchangmycin Chemical Structure

Nanchangmycin Chemical Structure

CAS No. 65101-87-3

Purity & Quality Control

Nanchangmycin Related Products

Biological Activity

Description Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.
Features Polyether antibiotic produced by Streptomyces nanchangensis NS3226.
In vitro
In vitro Nanchangmycin inhibits gram-positive bacteria. [1]
Cell Research Cell lines U2OS
Concentrations 0.7 μM
Incubation Time 1 h
Method

5000 cells were plated in 25ul media per well in 384-well plates. The next day, 50 nl of drugs were transfered to each well for a final concentration of 0.7uM/0.2% DMSO in U2OS. The drug treated U2OS cells were infected with Zika MR766, MOI=0.125 and fixed at 48 hours post infection (hpi).
In Vivo
In vivo Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens[1]. Nanchangmycin is a bacterially-derived natural product that potently blocked ZIKV infection across diverse cell types. It blocks ZIKV entry, as well as DENV infection[2].

Chemical Information & Solubility

Molecular Weight 889.1 Formula

C48H80O13
CAS No. 65101-87-3 SDF Download Nanchangmycin SDF
Smiles CC1CC(C(OC1C2CC(C3(O2)C(C(CC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C=C(C)C(=O)C(C)CC(C)C(=O)[O-])C)O)C)OC6CCC(C(O6)C)OC)C)C)(CO)O)C.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 173 mg/mL ( (194.57 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 173 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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