Home Angiogenesis FAK inhibitor Solanesol (Nonaisoprenol) For research use only.

Solanesol (Nonaisoprenol)

Synonyms: Nonaisoprenol, Betulanonaprenol

Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.

Solanesol (Nonaisoprenol) Chemical Structure

Solanesol (Nonaisoprenol) Chemical Structure

CAS No. 13190-97-1

Purity & Quality Control

Batch: S236001 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.05%
99.05

Solanesol (Nonaisoprenol) Related Products

Signaling Pathway

FAK Signaling Pathways

FAK Signaling Pathway

Biological Activity

Description Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
Targets
FAK [1]
In vitro
In vitro Solanesol is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK)[1]. Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. Solanesol also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects[2].
Cell Research Cell lines normal human hepatic cell L02
Concentrations 10, 50, 100, 250, 500, 1000 μM
Incubation Time 12 h
Method

Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm.

Chemical Information & Solubility

Molecular Weight 631.07 Formula

C45H74O
CAS No. 13190-97-1 SDF Download Solanesol (Nonaisoprenol) SDF
Smiles CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (158.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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