Home Neuronal Signaling COX inhibitor Salicylic acid For research use only.

Salicylic acid

Synonyms: 2-Hydroxybenzoic acid

Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.

Salicylic acid Chemical Structure

Salicylic acid Chemical Structure

CAS No. 69-72-7

Purity & Quality Control

Salicylic acid Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
Targets
Ethylene biosynthesis [4] COX [1]
In vitro
In vitro Salicylic acid (SA) is a phenolic phytohormone involved in plant defence against pathogens. It significantly stimulated PON1 activity in a concentration dependent manner[3].
In Vivo
In vivo Although oral SA (5.5 mg/kg body weight) during the Hg(0) exposure did not reduce the Hg levels in these organs, it effectively counteracted the Hg(0)-induced growth inhibition, and improved the behavioral performance, accompanied by a series of ameliorations in the antioxidative defense and anti-inflammatory response[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05712837 Completed
Acne Vulgaris
Combined Military Hospital Abbottabad
 June 1 2022 Not Applicable
NCT05166096 Completed
Healthy
Rhoshan Pharmaceuticals Inc
 December 3 2021 Phase 1
NCT04811625 Completed
Healthy Volunteers
PLx Pharma
 April 28 2021 Phase 4
NCT04792723 Unknown status
Cardiovascular Diseases
Vita Green Health Products Co. Ltd
 March 5 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 138.12 Formula

C7H6O3
CAS No. 69-72-7 SDF Download Salicylic acid SDF
Smiles C1=CC=C(C(=C1)C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 27 mg/mL ( (195.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 27 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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