Home Cytoskeletal Signaling Microtubule Associated inhibitor RMC-4630 For research use only.

RMC-4630

Synonyms: SSE15206

RMC-4630 (SSE15206) is an inhibitor of microtubule polymerization with a GI50 of 197 nM in HCT116 cells. It can overcome multidrug resistance and cause aberrant mitosis, resulting in G2/M arrest due to incomplete spindle formation in cancer cells.

RMC-4630 Chemical Structure

RMC-4630 Chemical Structure

CAS No. 2172652-48-9

Purity & Quality Control

Batch: S996901 DMSO]45 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.07%
99.07

RMC-4630 Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Biological Activity

Description RMC-4630 (SSE15206) is an inhibitor of microtubule polymerization with a GI50 of 197 nM in HCT116 cells. It can overcome multidrug resistance and cause aberrant mitosis, resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
Targets
microtubule polymerization [1]
197 nM(GI50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04916236 Recruiting
Pancreatic Cancer|Colorectal Cancer|Non-small Cell Lung Cancer|KRAS Mutation-Related Tumors
The Netherlands Cancer Institute|Lustgarten Foundation
 March 31 2022 Phase 1
NCT05054725 Active not recruiting
Non-Small Cell Lung Cancer
Revolution Medicines Inc.|Sanofi|Amgen
 December 30 2021 Phase 2

Chemical Information & Solubility

Molecular Weight 450.99 Formula

C20H27ClN6O2S
CAS No. 2172652-48-9 SDF Download RMC-4630 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (99.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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