Home Transmembrane Transporters TRP Channel activator - Sodium Channel inhibitor QX-314 chloride For research use only.

QX-314 chloride

QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.

QX-314 chloride Chemical Structure

QX-314 chloride Chemical Structure

CAS No. 5369-03-9

Purity & Quality Control

QX-314 chloride Related Products

Biological Activity

Description QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.
Targets
TRPV1 [1] TRPA1 [1] sodium channel [1]
In vitro
In vitro

As a sodium channel blocker, QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca<sup>2+</sup> currents are on average <45% of control amplitude.<sup><a class="sref"href="#s_ref">[1]</a></sup> <sup><a class="sref"href="#s_ref">[2]</a></sup>

Chemical Information & Solubility

Molecular Weight 298.85 Formula

C16H27ClN2O
CAS No. 5369-03-9 SDF --
Smiles [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 60 mg/mL ( (200.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 60 mg/mL

Ethanol : 60 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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