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Technical Data
| Formula | C16H27ClN2O |
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| Molecular Weight | 298.85 | CAS No. | 5369-03-9 | |
| Solubility (25°C)* | In vitro | DMSO | 60 mg/mL (200.76 mM) | |
| Water | 60 mg/mL (200.76 mM) | |||
| Ethanol | 60 mg/mL (200.76 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels. | ||||||
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| Targets |
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| In vitro | As a sodium channel blocker, QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca<sup>2+</sup> currents are on average <45% of control amplitude.<sup><a class="sref"href="#s_ref">[1]</a></sup> <sup><a class="sref"href="#s_ref">[2]</a></sup> |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.