Home Transmembrane Transporters Sodium Channel inhibitor Quinidine hemisulfate hydrate For research use only.

Quinidine hemisulfate hydrate

Synonyms: Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

Quinidine hemisulfate hydrate Chemical Structure

Quinidine hemisulfate hydrate Chemical Structure

CAS No. 6591-63-5

Purity & Quality Control

Quinidine hemisulfate hydrate Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Targets
Sodium channel [1]
In vitro
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates[1].
Cell Research Cell lines HMM cell lines HIB, and TRA
Concentrations 2.5, 5, 10, 25 μM
Incubation Time 4 days
Method

Cells were cultured on T25 cm2 flasks in the presence of different concentrations of quinidine for 4 days. Bromodeoxyuridine was added for 8.5 hours, after which cells were trypsinized and spun down for 10 minutes at 1500 revolutions per minute. Cells were washed twice in 1% BSA/phosphate-buffered saline (PBS) and fixed with 70% ethanol on ice. DNA was denatured by 2N HCl/Triton X100 at room temperature for 30 minutes and sodium tetraborate was added to neutralize the pH level. After centrifugation, cells were resuspended in 1% BSA/0.5% Tween 20/PBS and the cell concentration was adjusted to 1 x 106 cells per test.
In Vivo
In vivo

Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo[2].
Animal Research Animal Models Lewis rats
Dosages 80 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 391.47 Formula

C20H24N2O2.1/2H2SO4.H2O
CAS No. 6591-63-5 SDF Download Quinidine hemisulfate hydrate SDF
Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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