Home Neuronal Signaling 5-HT Receptor agonist - Dopamine Receptor antagonist Quetiapine For research use only.

Quetiapine

Synonyms: ICI204636

Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.

Quetiapine Chemical Structure

Quetiapine Chemical Structure

CAS No. 111974-69-7

Purity & Quality Control

Batch: S574101 DMSO]77 mg/mL]false]]]false]]]false Purity: 99.96%
99.96

Quetiapine Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05793632 Completed
Delirium
Ain Shams University
 March 1 2023 Phase 2
NCT05303935 Completed
Sleep Apnea Obstructive
Flinders University
 May 25 2022 Phase 2
NCT05374356 Unknown status
Post-Operative Confusion
University of Manitoba
 May 2022 Not Applicable
NCT04229875 Recruiting
Bipolar Disorder
Mental Health Services in the Capital Region Denmark|Maria Faurholt-Jepsen MD DMSc|The Mental Health Services in the Capital Region of Denmark
 January 13 2020 Not Applicable

Chemical Information & Solubility

Molecular Weight 383.51 Formula

C21H25N3O2S
CAS No. 111974-69-7 SDF --
Smiles C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (200.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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