Home Transmembrane Transporters Sodium Channel antagonist Proparacaine HCl For research use only.

Proparacaine HCl

Synonyms: Proxymetacaine Hydrochloride

Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Proparacaine HCl Chemical Structure

Proparacaine HCl Chemical Structure

CAS No. 5875-06-9

Purity & Quality Control

Batch: S182801 Water]66 mg/mL]false]DMSO]12 mg/mL]false]Ethanol]Insoluble]false Purity: 99.60%
99.60

Proparacaine HCl Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
Targets
Voltage-gated sodium channel [1]
3.4 mM(ED50)
In vitro
In vitro

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]
In Vivo
In vivo

Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]
Animal Research Animal Models Male Sprague–Dawley rats
Dosages ~10 μmol/kg
Administration Intrathecally

Chemical Information & Solubility

Molecular Weight 330.85 Formula

C16H26N2O3.HCl
CAS No. 5875-06-9 SDF Download Proparacaine HCl SDF
Smiles CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 66 mg/mL

DMSO : 12 mg/mL ( (36.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

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