Proparacaine HCl

Catalog No.S1828 Batch:S182801

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Technical Data

Formula

C16H26N2O3.HCl
Molecular Weight 330.85 CAS No. 5875-06-9
Solubility (25°C)* In vitro Water 66 mg/mL (199.48 mM)
DMSO 12 mg/mL (36.27 mM)
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
Saline
30.0mg/ml Taking the 1 mL working solution as an example, add 30 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
Targets
Voltage-gated sodium channel [1]
3.4 mM(ED50)
In vitro

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]
In vivo

Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]

Protocol (from reference)

Animal Study:

[4]
  • Animal Models

    Male Sprague–Dawley rats

  • Dosages

    ~10 μmol/kg

  • Administration

    Intrathecally

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.