Home GPCR & G Protein 5-HT Receptor inhibitor Pimavanserin tartrate For research use only.

Pimavanserin tartrate

Synonyms: ACP-103

Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.

Pimavanserin tartrate Chemical Structure

Pimavanserin tartrate Chemical Structure

CAS No. 706782-28-7

Purity & Quality Control

Pimavanserin tartrate Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.
Targets
5-HT2A [1]
(cell-based assay)
8.7(pIC50)
In Vivo
In vivo

In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. [1] In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements. [2]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 3 mg/kg
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05796167 Recruiting
Parkinson Disease
State University of New York - Downstate Medical Center|ACADIA Pharmaceuticals Inc.
 April 4 2024 Early Phase 1
NCT05555615 Recruiting
Irritability Associated With Autism Spectrum Disorder
ACADIA Pharmaceuticals Inc.
 November 2 2022 Phase 2|Phase 3
NCT04794413 Completed
Tourette Syndrome|Tardive Dyskinesia
Joseph Jankovic|Andrew Billnitzer MD|Baylor College of Medicine
 November 12 2018 Early Phase 1
NCT03121586 Active not recruiting
Schizophrenia
ACADIA Pharmaceuticals Inc.
 January 2017 Phase 3
NCT00087542 Completed
Hallucinations|Psychoses|Parkinson''s Disease
ACADIA Pharmaceuticals Inc.
 March 2004 Phase 2

Chemical Information & Solubility

Molecular Weight 1005.2 Formula

C50H68F2N6O4.C4H6O6
CAS No. 706782-28-7 SDF Download Pimavanserin tartrate SDF
Smiles CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.C(C(C(=O)O)O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (99.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 25 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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