Home Neuronal Signaling AChR agonist Pilocarpine HCl For research use only.

Pilocarpine HCl

Synonyms: NSC 5746 HCl

Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

Pilocarpine HCl Chemical Structure

Pilocarpine HCl Chemical Structure

CAS No. 54-71-7

Purity & Quality Control

Pilocarpine HCl Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
Targets
mAChR [1]
In vitro
In vitro Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at themuscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia. Pilocarpine acts on a subtype of muscarinic receptor (M3) found on the iris sphincter muscle, causing the muscle to contract and engage in miosis. [1] Pilocarpine also acts on the ciliary muscle and causes it to contract. When the ciliary muscle contracts, it opens the trabecular meshwork through increased tension on the scleral spur. This action facilitates the rate that aqueous humorleaves the eye to decrease intraocular pressure. In ophthalmology, pilocarpine is also used to reduce the possibility of glare at night from lights when the patient has undergone implantation of phakic intraocular lenses; the use of pilocarpine would reduce the size of the pupils, relieving these symptoms. The most common concentration for this use is pilocarpine 1%, the weakest concentration. Pilocarpine is also used to treat dry mouth (xerostomia) which can occur, for example, as a side effect of radiation therapy for head and neck cancers. Pilocarpine stimulates the secretion of large amounts of saliva and sweat.[2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05506137 Not yet recruiting
Xerostomia|Dry Mouth
Maastricht University Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development
 January 2023 Phase 3
NCT05564832 Recruiting
Near Vision
Shahid Beheshti University of Medical Sciences
 August 1 2022 Early Phase 1
NCT05006898 Completed
Presbyopia
Optall Vision
 June 1 2020 Phase 1
NCT04005079 Withdrawn
Open Angle Glaucoma|Ocular Hypertension
Montefiore Medical Center
 June 5 2019 Phase 3
NCT03912792 Withdrawn
XLHED
Dermelix Biotherapeutics LLC.
 June 28 2019 --

Chemical Information & Solubility

Molecular Weight 244.72 Formula

C11H16N2O2.HCl
CAS No. 54-71-7 SDF Download Pilocarpine HCl SDF
Smiles CCC1C(COC1=O)CC2=CN=CN2C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (200.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 49 mg/mL

Ethanol : 49 mg/mL


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In vivo
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