Home Metabolism MAO inhibitor Pargyline hydrochloride For research use only.

Pargyline hydrochloride

Synonyms: Pargylamine hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

Pargyline hydrochloride Chemical Structure

Pargyline hydrochloride Chemical Structure

CAS No. 306-07-0

Purity & Quality Control

Pargyline hydrochloride Related Products

Signaling Pathway

MAO Signaling Pathways

MAO Signaling Pathway

Biological Activity

Description Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.
Targets
MAO-B [1]
(Cell-free assay)		 MAO-A [1]
(Cell-free assay)
0.5 μM(Ki) 13 μM(Ki)
In vitro
In vitro Pargyline, an MAO inhibitor, prevents the activity of lysine-specific demethylase 1 (LSD1) and is excessively expressed in breast cancer. The proliferation of cells exposed to pargyline decreases in a dose- and time-dependent manner. The treatment of 2 mM pargyline exhibits an increase of the cell proportion at the G1 phase, while the major decrease of the cell proportion is at the S phase. pargyline induces an increase in the cleaved PARP expression[2].
Cell Research Cell lines T47D cells
Concentrations 0.5, 1, 1.5 and 2 mM
Incubation Time 24, 48, 72, 96 and 120 h
Method --
In Vivo
In vivo Chronic treatment (14 days) with pargyline (10 mg/kg) markedly down-regulate the density of NAIBS (non-adrenoceptor idazoxan binding sites) in the rat brain[3].
Animal Research Animal Models Sprague-Dawley rats
Dosages 10 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 195.69 Formula

C11H13N.HCl
CAS No. 306-07-0 SDF Download Pargyline hydrochloride SDF
Smiles CN(CC#C)CC1=CC=CC=C1.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (199.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 39 mg/mL

Ethanol : 39 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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