Home Metabolism MAO inhibitor Paeonol For research use only.

Paeonol

Synonyms: Peonol

Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.

Paeonol Chemical Structure

Paeonol Chemical Structure

CAS No. 552-41-0

Purity & Quality Control

Paeonol Related Products

Signaling Pathway

MAO Signaling Pathways

MAO Signaling Pathway

Biological Activity

Description Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.
Targets
MAO-B [1] MAO-A [1]
42.5 μM 54.6 μM
In vitro
In vitro Paeonol (Peonol) is a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum. It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively. [1] Paeonol shows antimutagenic, anti-inflammatory and analgesic effects. [2] Paeonol also inhibits anaphylactic reaction by regulating histamine and TNF-α. [3]
In Vivo
In vivo LD50: Mice 608-899mg/kg (i.p.). [4]

Chemical Information & Solubility

Molecular Weight 166.17 Formula

C9H10O3
CAS No. 552-41-0 SDF Download Paeonol SDF
Smiles CC(=O)C1=C(C=C(C=C1)OC)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (198.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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