Home Neuronal Signaling 5-HT Receptor antagonist Palonosetron HCl For research use only.

Palonosetron HCl

Synonyms: RS 25259, RS 25259 197

Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Palonosetron HCl Chemical Structure

Palonosetron HCl Chemical Structure

CAS No. 135729-62-3

Purity & Quality Control

Palonosetron HCl Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Targets
5-HT3 [1]
In vitro
In vitro Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ∼100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ∼40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04486157 Completed
Healthy
HK inno.N Corporation
 March 18 2021 Phase 1
NCT04466046 Completed
Postoperative Nausea and Vomiting
Daegu Catholic University Medical Center
 September 4 2019 --
NCT03148704 Unknown status
Palonosetron
Cttq
 March 8 2017 --
NCT00982995 Terminated
Nausea|Vomiting|Terminally Ill
University of Michigan Rogel Cancer Center
 November 2010 Phase 2
NCT01074697 Completed
Nausea|Vomiting|Genital Neoplasms Female
Odense University Hospital|Helsinn Healthcare SA
 April 2010 Phase 3

Chemical Information & Solubility

Molecular Weight 332.87 Formula

C19H24N2O.HCl
CAS No. 135729-62-3 SDF Download Palonosetron HCl SDF
Smiles C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 67 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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