Home Metabolism COX inhibitor Oxaprozin For research use only.

Oxaprozin

Synonyms: WY-21743,nsc 310839

Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

Oxaprozin Chemical Structure

Oxaprozin Chemical Structure

CAS No. 21256-18-8

Purity & Quality Control

Oxaprozin Related Products

Signaling Pathway

COX Signaling Pathways

COX Signaling Pathway

Biological Activity

Description Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Targets
COX1 [1] COX-2 [1]
In vitro
In vitro

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity. [1]

Chemical Information & Solubility

Molecular Weight 293.32 Formula

C18H15NO3
CAS No. 21256-18-8 SDF Download Oxaprozin SDF
Smiles C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (197.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 58 mg/mL

Water : Insoluble


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In vivo
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