Home JAK/STAT JAK inhibitor NSC 42834 For research use only.

NSC 42834

Synonyms: JAK2 Inhibitor V, Z3

NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.

NSC 42834 Chemical Structure

NSC 42834 Chemical Structure

CAS No. 195371-52-9

Purity & Quality Control

NSC 42834 Related Products

Signaling Pathway

JAK Signaling Pathways

JAK Signaling Pathway

Biological Activity

Description NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.
Targets
JAK2 (WT) [1] JAK2 (V617F) [1]

Chemical Information & Solubility

Molecular Weight 344.45 Formula

C23H24N2O
CAS No. 195371-52-9 SDF --
Density 1.25 g/mL at 20 °C
Smiles CC(CCC1=CC=CC=N1)(CCC2=CC=CC=N2)C(=O)C3=CC=CC=C3
Storage (From the date of receipt) 2 years -20°C liquid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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