Home Immunology & Inflammation Arginase inhibitor Nor-NOHA acetate For research use only.

Nor-NOHA acetate

Synonyms: Nω-Hydroxy-nor-L-Arginine acetate salt, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate

Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM).

Nor-NOHA acetate Chemical Structure

Nor-NOHA acetate Chemical Structure

CAS No. 1140844-63-8

Purity & Quality Control

Nor-NOHA acetate Related Products

Biological Activity

Description Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM).
Targets
liver arginase [1]
(Cell-free assay)
0.5 μM
In vitro
In vitro

Nor-NOHA is a very potent competitive inhibitor of rat liver arginase in vitro with the Ki of 0.5 μM.[2]
In Vivo
In vivo

Nor-NOHA significantly prevents the increase in IL-6 and VEGF levels and improves vascular function in Adjuvant-induced arthritis (AIA) rats.[1]
Animal Research Animal Models Adjuvant-induced arthritis (AIA) rats
Dosages 40 mg/kg/day
Administration i.p.

Chemical Information & Solubility

Molecular Weight 296.28 Formula

C9H20N4O7
CAS No. 1140844-63-8 SDF --
Smiles CC(O)=O.CC(O)=O.NC(CCN/C(N)=N/O)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (168.75 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : 29 mg/mL


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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