Home Immunology & Inflammation Arginase inhibitor BEC HCl For research use only.

BEC HCl

BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

BEC HCl Chemical Structure

BEC HCl Chemical Structure

CAS No. 222638-67-7

Purity & Quality Control

Batch: S792901 DMSO]45 mg/mL]false]Water]45 mg/mL]false]Ethanol]45 mg/mL]false Purity: 99.89%
99.89

BEC HCl Related Products

Biological Activity

Description BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
Targets
Arginase II [1] rat Arginase I [2]
0.31 μM(Ki) <0.6 μM(Ki)
In vitro
In vitro BEC causes significant enhancement of NO-dependent smooth muscle relaxation. [2] In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. [3] BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. [5]
In Vivo
In vivo In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. [4] In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure. [5]
Animal Research Animal Models Mice with allergic inflammation (OVA/OVA)
Dosages 0.30 mM, 40 μl
Administration oropharyngeal aspiration

Chemical Information & Solubility

Molecular Weight 229.49 Formula

C5H12BNO4S.HCl
CAS No. 222638-67-7 SDF Download BEC HCl SDF
Smiles B(CCSCC(C(=O)O)N)(O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (196.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 45 mg/mL

Ethanol : 45 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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