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Technical Data
| Formula | C5H12BNO4S.HCl |
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| Molecular Weight | 229.49 | CAS No. | 222638-67-7 | |
| Solubility (25°C)* | In vitro | DMSO | 45 mg/mL (196.08 mM) | |
| Water | 45 mg/mL (196.08 mM) | |||
| Ethanol | 45 mg/mL (196.08 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively. | ||||
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| Targets |
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| In vitro | BEC causes significant enhancement of NO-dependent smooth muscle relaxation. [2] In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. [3] BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. [5] | ||||
| In vivo | In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. [4] In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure. [5] |
Protocol (from reference)
| Animal Study:[4] |
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References
Selleck's BEC HCl has been cited by 4 publications
| Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine [ Cell Rep, 2024, 43(7):114490] | PubMed: 38990720 |
| l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy [ J Orthop Translat, 2024, 46:53-64] | PubMed: 38808262 |
| Warburg effect-related risk scoring model to assess clinical significance and immunity characteristics of glioblastoma [ Cancer Med, 2023, 10.1002/cam4.6627] | PubMed: 37864422 |
| The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia [ iScience, 2022, 25(3):103881] | PubMed: 35243242 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.