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Technical Data
| Formula | C9H20N4O7 |
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| Molecular Weight | 296.28 | CAS No. | 1140844-63-8 | |
| Solubility (25°C)* | In vitro | DMSO | 50 mg/mL (168.75 mM) | |
| Water | 50 mg/mL (168.75 mM) | |||
| Ethanol | 50 mg/mL (168.75 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM). | ||
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| Targets |
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| In vitro | Nor-NOHA is a very potent competitive inhibitor of rat liver arginase in vitro with the Ki of 0.5 μM.[2] |
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| In vivo | Nor-NOHA significantly prevents the increase in IL-6 and VEGF levels and improves vascular function in Adjuvant-induced arthritis (AIA) rats.[1] |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Nor-NOHA acetate has been cited by 1 publication
| Skin repair and immunoregulatory effects of myeloid suppressor cells from human cord blood in atopic dermatitis [ Front Immunol, 2023, 14:1263646] | PubMed: 38264643 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.