Home Neuronal Signaling 5-HT Receptor agonist NLX-101 For research use only.

NLX-101

Synonyms: F-15599

NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors.

NLX-101 Chemical Structure

NLX-101 Chemical Structure

CAS No. 635323-95-4

Purity & Quality Control

Batch: S351001 DMSO]79 mg/mL]false]Ethanol]79 mg/mL]false]Water]Insoluble]false Purity: 99.86%
99.86

NLX-101 Related Products

Signaling Pathway

5-HT Receptor Signaling Pathways

5-HT Receptor Signaling Pathway

Biological Activity

Description NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors.
Targets
5-HT1A receptor [1]
In Vivo
In vivo

NLX-101, an activator of 5-HT1A receptors in the prefrontal cortex (PFC), produces robust antidepressant-like effects in the rat FST, with a distinctive bimodal doseresponse pattern, suggestting that NLX-101 may target specific 5-HT1A receptor subpopulations in PFC, likely located on GABAergic and/or glutamatergic neuron.[1]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 0.25 and 16 μg
Administration s.c.

Chemical Information & Solubility

Molecular Weight Formula
CAS No. 635323-95-4 SDF --
Smiles CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C3=CC(=C(F)C=C3)Cl)N=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 79 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : Insoluble


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In vivo
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